Utilizing Adeno-Associated Virus Vectors for Advancing Cancer Gene Therapy
DOI:
https://doi.org/10.62051/1s4q1d83Keywords:
Adeno-associated virus; gene therapy; cancer treatment; tumor models.Abstract
Adeno-associated virus (AAV) has proven highly effective as a delivery vector in clinical trials for gene therapy. The safety and efficacy of AAV have led to its application as a novel approach for cancer treatment. Many successful clinical trials of cancer have demonstrated the feasibility of this approach. This review mainly introduces the structure, characteristics and application of AAV in tumor models. The promise of gene therapy in addressing diverse diseases has become evident, with AAV vectors playing a pivotal role in its achievements. AAV's exceptional safety profile and efficacy in gene therapy have spurred their application as a novel approach in the realm of cancer treatment. Clinical trials in this area have yielded impressive results, underlining the potential of AAV in combating cancer. This review provides a comprehensive insight into AAV's structural attributes and unique characteristics, emphasizing their significance in the context of tumor models. AAV's ability to efficiently deliver therapeutic genes to cancer cells, coupled with minimal risk, marks a significant breakthrough in oncology.
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References
B.S. Chhikara, K. Parang, Chem. Biol. Lett., 10, 451 (2023).
C. Sonigo, I. Beau, N. Binart, M. Grynberg, Int. J. Mol. Sci., 20, 5342 (2019).
E. Hanna, C. Rémuzat, P. Auquier, M. Toumi, JMAHP., 5, 1265293 (2017).
H. Zu, D. Gao, AAPS J., 23, 78 (2021).
J.N. Warnock, C. Daigre, M. Al-Rubeai, Methods Mol. Biol., 737, 1(2011).
D. Bouard, N. Alazard-Dany, F.-L. Cosset, BRIT J PHARMACOL., 157, 153 (2009).
Y. Qu, Y. Liu, A. F. Noor, J. Tran, R. Li, Neural Regen Res., 14, 931 (2019).
M.F. Naso, B. Tomkowicz, W. L. Perry, BioDrugs, 31, 317 (2017).
J.L. Santiago-Ortiz, D.V. Schaffer, J Control Release, 240, 287 - 301 (2016).
D. Wang, P. W. Tai, G. Gao, Nat. Rev. Drug Discov., 18, 358 (2019).
J. F. Wright, Gene Ther., 15, 840 (2008).
C. Li, R. J. Samulski, Nat. Rev. Genet., 21, 255 (2020).
J. L. Santiago-Ortiz, D. V. Schaffer, J Control Release, 240, 287 (2016).
Z. Wu, A. Asokan, R. J. Samulski, Mol. Ther., 14, 316 (2006).
R. Waehler, S. J. Russell, D. T. Curiel, Nat. Rev. Genet., 8, 573 (2007).
F. Shojaei, Cancer Lett., 320, 130 (2012).
S. Rafii, D. Lyden, R. Benezra, K. Hattori, B. Heissig, Nat. Rev. Cancer, 2, 826 (2002).
P. Trang, J. F. Wiggins, C. L. Daige, C. Cho, M. Omotola, D. Brown, F. J. Slack, Mol. Ther., 19, 1116 (2011).
Z. Xue, P. H. Sun, L. M. Zhu, S. H. Jiang, M. M. Qiao, A. L. Chi, S. P. Tu, Oncol. Rep., 25, 1039 (2011).
S. Fumoto, S. Kawakami, M. Hashida, K. Nishida, Gene Ther., 3 (2013).
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