Progress of Ginsenosides on Immunomodulation and Inhibition of Lung Cancer
DOI:
https://doi.org/10.62051/jrk15c25Keywords:
Ginsenosides; lung cancer; immune system.Abstract
Ginseng is characterized by low toxicity, multi-targeting and enhancement of body immunity in its anti-cancer effects. Ginsenosides are natural effective anti-cancer components, mainly consisting of diol-type, triol-type, and oleanolic acid-type ginsenosides. Ginsenosides are bio absorbed by intestinal flora through "Rb1-Gibberellin XVII-F2-CK-PPD", "Rb2-Rd-F2-CK-PPD", "Rg3-Rh2-PPD" and other pathways. It can be converted into saponins ck, Rh1, Rh2, Rc, PPD and other active ingredients. Metabolites of ginsenosides are used in the treatment of many types of cancers and have been shown to be effective. They function by modulating various immune cells in the body, for example, ginsenoside Rh2 significantly increases T-lymphocyte activity and significantly induces differentiation of M2 macrophages towards the M1 phenotype. Ginsenoside Rg3 can act as a cytotoxic activator of NK cells, which inhibits the growth of tumor cells and induces apoptosis and autophagy of tumor cells, and plays an inhibitory and therapeutic role in lung cancer and a variety of tumors, with certain prospects for application development. This review introduces mechanism and function of ginsenosides and discusses application in lung cancer.
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[1] Chen F. Ex vivo and in vivo anti-tumour effect of ginsenoside Rh2 octanoate derivatives and its mechanism[D]. Nanchang University, 2016: 182
[2] CHEN Danqing, ZHENG Yanyan, et al. Research progress on anti-tumour mechanism of ginsenoside-related metabolites[J]. Journal of Shanghai University of Traditional Chinese Medicine, 2023, 37(5):83-86
[3] Han Ning, Li Qiushi, et al. Effect and mechanism of ginsenosides Rg3 in inhibiting proliferation and invasion of lung cancer cells [J]. Chinese Journal of Clinical Pharmacy, 2019, 39 (20): 2945. (In Chinese
[4] Ma Chuangui, Zhang Zhixiu, et al. Research progress on anti-tumour and immunomodulatory effects of ginsenosides[J]. Special Economic Animals and Plants, 2024, 27(03):182
[5] Zhang Yan, Zhou Shuru, et al. Regulation of ginsenosides on immune function and its mechanism [J]. Journal of Jiangsu University (Med Edition), 1023,33 (5): 456-457. (In Chinese
[6] Chen L, Tu J, et al. Effects of ginsenoside Rg3 and cisplatin on immune function and tumour-associated proteins in nude mice with Dutch ovarian cancer[J]. Journal of Oncology, 2014, 20(11):916
[7] Li Mo. Study on the mechanism of ginsenoside Rg5 promoting apoptosis and cell cycle arrest in human lung adenocarcinoma by ROS-mediated JNK/p38 MAPK activation [D]. Jilin University, 2023:345
[8] WANG Z H. Autophagy induced by ginsenoside Rh2 in mouse melanoma B16 cells and its mechanism [D]. Dalian Medical University, 2015:2
[9] ADAMS S J, STONE E, BALDWIN D R, et al. Lung cancer screening[J]. Lancet, 2023,401(10374):390-408.
[10] Deng J. The inhibitory effect of ginsenoside CK combined with cisplatin on human lung adenocarcinoma A549 cell line [D], Kunming Medical College, 2010:14-15
[11] HUI Xiaona, HU Pei, et al. Research progress on the effect of intestinal flora on the activity of ginsenosides against lung cancer[J]. Pharmacology and Clinic of Traditional Chinese Medicine, 201733(1):218
[12] Wang Aihua, Liu Wei, et al. Ginsenoside Rg3: a potential natural drug for the treatment of non-small cell lung cancer [J], Chinese Journal of Traditional Chinese Medicine, 202, 40 (2) : 157
[13] Lin X, Wang F, et al. Ginsenoside Rg3 combined with apatinib promotes immune response in lung cancer cells with inducible co-stimulatory molecule (ICOS) upregulation. Journal of Immunology, 2019, 35(2):141-142
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