Update on The Risk Factors and Treatment Options for Rheumatoid Arthritis

Authors

  • Pengyu Chen
  • Yicheng Gan
  • Jingxue Lin
  • Wanxin Zhao

DOI:

https://doi.org/10.62051/dz3mea16

Keywords:

Rheumatoid arthritis; risk factors; treatment.

Abstract

Rheumatoid arthritis (RA) is characterized by inflammation of the surrounding joints and tissue hyperplasia, which affect all joints in the body. Although RA is generally not fatal, extrarthral lesions may have adverse consequences, which should be paid enough attention to. At present, the treatment mainly relies on anti-inflammatory, analgesic and immunosuppressive drugs, but the problems of relapse and the adverse drug reactions are still faced. This paper introduces the different high-risk factors of the disease, and the related drug and non-drug intervention measures. At the same time, it expounds the new targets of current treatment, such as psychological intervention, exercise intervention, diet intervention, traditional Chinese medicine intervention, and non-drug intervention assisted by digital remote monitoring. To further reduce the disease progression of RA, and to provide reference for improving the life quality and carrying out continuous care, the problems of the intervention methods were summarized and the prospects for future research were put forward.

Downloads

Download data is not yet available.

References

[1] Brown P, Pratt AG, Hyrich KL. Therapeutic advances in rheumatoid arthritis. BMJ. 2024 Jan 17;384: e070856.

[2] Deane K D, Demoruelle M K, Kelmenson L. B, et al. Genetic and environmental risk factors for rheumatoid arthritis [JJ. Best practice & research Clinical rheumatology, 2017, 31(1): 3-18.

[3] Padyukov L. Genetics of rheumatoid arthritis. Semin Immunopathol. 2022 Jan;44(1):47-62.

[4] somäki P, Punnonen J. Pro-and anti-inflammatory cytokines in rheumatoid arthritis[J]. Annals of medicine, 1997, 29(6): 499-507.

[5] Qiu Anqi. Research progress of cytokines in the pathogenesis of rheumatoid arthritis [J]. Laboratory Medicine & Clinic, 2019,20(6):830-834.

[6] Peng Y, Huang Y, Li H, Li C, Wu Y, Wang X, Wang Q, He J, Miao C. Associations between rheumatoid arthritis and intestinal flora, with special emphasis on RA pathologic mechanisms to treatment strategies. Microb Pathog. 2024 Mar; 188:106563.

[7] Zaccardelli A, Friedlander HM, Ford JA, Sparks JA. Potential of Lifestyle Changes for Reducing the Risk of Developing Rheumatoid Arthritis: Is an Ounce of Prevention Worth a Pound of Cure? Clin Ther. 2019 Jul;41(7):1323-1345.

[8] Friedman, Benjamin, and Bruce Cronstein. "Methotrexate mechanism in treatment of rheumatoid arthritis." Joint bone spine 86.3 (2019): 301-307.

[9] Zhang Yan, Wang Mingjie, Xue Yan, et al. Efficacy and safety analysis of different doses of Tofacatib combined with methotrexate in the treatment of rheumatoid arthritis and its effect on serum factor levels [J]. Journal of Practical Medicine, 2019,39(1):114-118.

[10] Wang, Wanying, Hua Zhou, and Liang Liu. "Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review." European journal of medicinal chemistry 158 (2018): 502-516.

[11] Shawky AM, Almalki FA, Abdalla AN, Abdelazeem AH, Gouda AM. A Comprehensive Overview of Globally Approved JAK Inhibitors. Pharmaceutics. 2022 May 6;14(5):1001.

Downloads

Published

24-12-2024

How to Cite

Chen, P., Gan, Y., Lin, J., & Zhao, W. (2024). Update on The Risk Factors and Treatment Options for Rheumatoid Arthritis. Transactions on Materials, Biotechnology and Life Sciences, 7, 313-317. https://doi.org/10.62051/dz3mea16