Genetics and Environmental Causes of Lung Cancer: Insights into KRAS, ALK, EGFR Mutations and the influence of Tobacco Smoking

Abstract

As a critical worldwide health issue, Lung cancer represents one of the leading causes of cancer-related mortality worldwide. Grasping the root causes of lung cancer is essential for creating and utilizing effective treatment strategies. This paper will explore four primary causes in-depth: tobacco smoking, KRAS mutation, ALK mutation, and EGFR mutation. Tobacco smoking, the most prevalent cause, introduces carcinogens that damage lung tissue, leading to cellular mutations. The KRAS mutation, found in about 25% of lung adenocarcinomas, results in uncontrolled cell growth and division by activating oncogenic pathways. The ALK mutation, present in approximately 5% of non-small cell lung cancers (NSCLC), involves a genetic rearrangement, creating a fusion gene that drives malignant cell proliferation. The GFR mutation, found in 10-15% of NSCLC cases, leads to uncontrollable and continuous Epidermal growth receptor activation, promoting uncontrolled cell division. Understanding these causes allows for specific therapies that target each cause to be formed, underpinning the development of diagnostic and therapeutic approaches, which offers hope for more personalized and effective treatments. This paper will also briefly discuss the current treatments for lung cancer, including targeted therapies for each cause of lung cancer and ongoing research aimed at improving patient outcomes.