Ω-3 PUFA DHA: Benefits Associated With Brain
DOI:
https://doi.org/10.62051/z3e6f320Keywords:
Ω-3; PUFA; fish oil; fetal development; AD.Abstract
DHA and EPA from fish oil are ΩΩ-3 polyunsaturated fatty acids which can’t be synthesized adequately in human body as the conversion from ALA and ARA is low. Thus, we can only get the recommended dose from marine animals and supplements at the natural ratio. Notably, global warming is predicted to decrease availability of this nutrient, and part of its role in the human body cannot be seen in the form of supplements. This review article summarizes the benefits of DHA on fetal development associated with the maternal supplementation. Fish oil can also influence APOE4-associated Alzheimer’s disease through the form of DHA-LPC (lysophosphatidylcholine). This review provides a fresh perspective on DHA.
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Colombo, S.M., Rodgers, T.F.M., Diamond, M.L. et al. Projected declines in global DHA availability for human consumption as a result of global warming. Ambio 49, 865–880 (2020). https://doi.org/10.1007/s13280-019-01234-6
Danielle Swanson, Robert Block, Shaker A. Mousa, Ω-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life, Advances in Nutrition, Volume 3, Issue 1, January 2012, Pages 1–7, https://doi.org/10.3945/an.111.000893
Adam H Metherel, Maha Irfan, Shannon L Klingel, David M Mutch, Richard P Bazinet, Compound-specific isotope analysis reveals no retroconversion of DHA to EPA but substantial conversion of EPA to DHA following supplementation: a randomized control trial, The American Journal of Clinical Nutrition, Volume 110, Issue 4, October 2019, Pages 823–831, https://doi.org/10.1093/ajcn/nqz097
Liu, JH., Wang, Q., You, QL. et al. Acute EPA-induced learning and memory impairment in mice is prevented by DHA. Nat Commun 11, 5465 (2020). https://doi.org/10.1038/s41467-020-19255-1
Mireille Guillot, Anne Synnes, Etienne Pronovost, Mosarrat Qureshi, Thierry Daboval, Georges Caouette, François Olivier, Julie Bartholomew, Ibrahim Mohamed, Edith Massé, Jehier Afifi, Leonora Hendson, Brigitte Lemyre, Thuy Mai Luu, Lannae Strueby, Zenon Cieslak, Kamran Yusuf, Gustavo Pelligra, Thierry Ducruet, Aissatou Bintou Khairy Thilor Ndiaye, Georgina Angoa, Thibaut Sériès, Bruno Piedboeuf, Anne Monique Nuyt, William Fraser, Benoît Mâsse, Thierry Lacaze-Masmonteil, Pascal M. Lavoie, Isabelle Marc; Maternal High-Dose DHA Supplementation and Neurodevelopment at 18–22 Months of Preterm Children. Pediatrics July 2022; 150 (1): e2021055819. 10.1542/peds.2021-055819
Berthold Koletzko, Karin Bergmann, J Thomas Brenna, Philip C Calder, Cristina Campoy, M Tom Clandinin, John Colombo, Mandy Daly, Tamás Decsi, Hans Demmelmair, Magnus Domellöf, Nataša FidlerMis, Ines Gonzalez-Casanova, Johannes B van Goudoever, Adamos Hadjipanayis, Olle Hernell, Alexandre Lapillonne, Silke Mader, Camilia R Martin, Valerie Matthäus, Usha Ramakrishan, Cornelius M Smuts, Sean J J Strain, Conny Tanjung, Patrick Tounian, Susan E Carlson, on behalf of the European Academy of Paediatrics and the Child Health Foundation, Should formula for infants provide arachidonic acid along with DHA? A position paper of the European Academy of Paediatrics and the Child Health Foundation, The American Journal of Clinical Nutrition, Volume 111, Issue 1, January 2020, Pages 10–16, https://doi.org/10.1093/ajcn/nqz252
Patrick, R.P. (2019), Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease. The FASEB Journal, 33: 1554-1564. https://doi.org/10.1096/fj.201801412R
Tomaszewski, Natalie et al. ‘Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer’s Disease Cooperative Study-Sponsored DHA Clinical Trial’. 1 Jan. 2020 : 975 – 990.
DhavamaniSugasini, Poorna C.R. Yalagala, Alexis Goggin, Leon M. Tai, Papasani V. Subbaiah, Enrichment of brain docosahexaenoic acid (DHA) is highly dependent upon the molecular carrier of dietary DHA: lysophosphatidylcholine is more efficient than either phosphatidylcholine or triacylglycerol, The Journal of Nutritional Biochemistry, Volume 74, December 2019, 108231.
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