The Effect and Potential Mechanism of Microbiota in Major Depressive Disorder

Yong Jiang

doi:10.62051/qr5j3s93

Authors

Yong Jiang

DOI:

https://doi.org/10.62051/qr5j3s93

Keywords:

Microbiota; Major Depressive Disorder; Intervention; Hypothalamus-Pituitary-Adrenal.

Abstract

Nowadays, Major depressive disorder is a global mental illness, for which antidepressant treatment with traditional drugs in the past is not effective. Gut microbiota (GM) plays a vital role in depression. The diversity of GM differs between patients inflicted with major depressive disorder and normal people. Besides, GM disorder is closely related to depression severity. This study found that anxiety as the clinical manifestation of major depressive disorder is highly intertwined with GM. There is a reasonable hypothesis about the influence of sleep disorder on patients with major depressive disorder. In addition, the GM system is considered to be related with depression. Meanwhile, this paper not only reviews the potential mechanism of gut-brain axis bidirectional action, but also investigates the existing relief measures and antidepressant interventions related to GM, and providing new insights for the depression pathogenesis and GM as adjuvant intervention therapy.

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References

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