NVTIA Four-Component Synovitis Therapeutic Composition for Cartilage Tissue Repair: Formulation Architecture, Preclinical Signals, and Published Translational Evidence
DOI:
https://doi.org/10.62051/ijphmr.v6n4.10Keywords:
Synovitis, Cartilage repair, Glucosamine hydrochloride, Chondroitin sulfate, Methylsulfonylmethane, Sodium hyaluronate, Formulation engineering, OsteoarthritisAbstract
This template explains and demonstrates how to prepare your camera-ready paper for Warwick Evans Publishing. The best is to read these instructions and follow the outline of this text. Please make the page settings of your word processor to A4 format (21 x 29.7 cm); with the margins: bottom 1.9 cm (0.74 in) and top 2.5 cm (0.98 in), right/left margins must be 2 cm (0.78 in). All manuscripts must be in English, also the table and figure texts, otherwise, we cannot publish your paper. All manuscripts must be in English, also the table and figure texts, otherwise, we cannot publish your paper.
References
[1] World Health Organization. Osteoarthritis. WHO Fact Sheet. Updated 14 July 2023.
[2] Chen B, Sun Y, Xu G, et al. Role of crosstalk between synovial cells and chondrocytes in osteoarthritis (Review). Exp Ther Med. 2024; 27:201. doi:10.3892/etm.2024.12490.
[3] Uitterlinden EJ, Koevoet JLM, Verkoelen CF, et al. Glucosamine increases hyaluronic acid production in human osteoarthritic synovium explants. BMC Musculoskelet Disord. 2008; 9:120. doi:10.1186/1471-2474-9-120.
[4] Rabade A, Viswanatha GL, Nandakumar K, Kishore A. Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis. Inflammopharmacology. 2024; 32(3):1759-1775. doi:10.1007/s10787-024-01460-9.
[5] Brito R, Barros P, Rodrigues L, et al. Chondroitin sulfate supplements for osteoarthritis: a critical review. Cureus. 2023; 15(6):e41038. PMID:37431333.
[6] Usha PR, Naidu MUR. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Investig. 2004; 24(6):353-363. doi:10.2165/00044011-200424060-00005.
[7] Toguchi A, Noguchi N, Kanno T, Yamada A. Methylsulfonylmethane improves knee quality of life in participants with mild knee pain: a randomized, double-blind, placebo-controlled trial. Nutrients. 2023; 15(13):2995. doi:10.3390/nu15132995.
[8] Migliorini F, Maffulli N, Schafer L, Kubach J, Betsch M, Pasurka M. Less pain with intra-articular hyaluronic acid injections for knee osteoarthritis compared to placebo: a systematic review and meta-analysis of randomised controlled trials. Pharmaceuticals (Basel). 2024; 17(11):1557. doi:10.3390/ph17111557.
[9] Glinkowski WM, Tomaszewski W. Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: A Systematic Umbrella Review. J Clin Med. 2025; 14(4):1272. doi:10.3390/jcm14041272.
[10] Migliorini F, Maffulli N, Nijboer CH, Pappalardo G, Pasurka M, Betsch M, et al. Comparison of different molecular weights of intra-articular hyaluronic acid injections for knee osteoarthritis: a level I Bayesian network meta-analysis. Biomedicines. 2025; 13(1):175. doi:10.3390/biomedicines13010175.
[11] Overton C, Nelson AE, Neogi T. Osteoarthritis treatment guidelines from six professional societies: similarities and differences. Rheum Dis Clin North Am. 2022; 48(3):637-657. doi:10.1016/j.rdc.2022.03.009.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 International Journal of Public Health and Medical Research

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.







