International Journal of Public Health and Medical Research
International Journal of Public Health and Medical Research (IJPHMR), a peer-reviewed open access journal published in English-language, provides an international platform for the publication and dissemination of original work that contributes to the understanding of the main and related disciplines of public health, life sciences, medicine, biotechnology either empirical or theoretical. The journal covers the whole spectrum of medicine & health, biotechnology& life sciences, and more.
Inhibitory Effect of Serum from Atherosclerotic Patients on Oxidized LDL Uptake by Macrophages
Introduction: Atherosclerotic antigens can elicit an adaptive immune response, resulting in increased levels of autoantibodies in patient serum. However, the direct effects of patient serum and its autoantibodies on lipid uptake and foam cell formation remain unexplored. Methods: In this study, we investigated the effects of patient serum and its autoantibodies on macrophage lipid phagocytosis and foam cell formation, as well as assessed the antibody status against the whole antigen of foam cells in the serum. Human serum, which included samples from forty-five patients and eight healthy individuals, was co-cultured with the oxidized LDL (ox-LDL) and macrophages, and then the effect of the serum on inhibiting ox-LDL lipid engulfment by macrophages was assessed. Next, the binding ability of human serum antibodies to foam cells was evaluated using ELISA and immunofluorescence staining. Results: Our results indicated that 17.8% of patient serum samples demonstrate a significant inhibition of ox-LDL uptake by macrophages (p < 0.05). Among these samples, ELISA and immunofluorescence staining results further revealed that the circulating IgG and IgM levels against foam cell antigens were significantly higher in patients than in healthy individuals. The IC50 value of purified antibodies from patients reached as low as 0.024 mg/mL in inhibiting ox-LDL uptake by macrophages, which is significantly lower than the IC50 value of 0.054 mg/mL observed in healthy individuals. Conclusion: This study provides new insights into the protective role of patient serum and its autoantibody against atherosclerosis.
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Public Health Implications of Violent Video Game Exposure: Effects on Adolescent Aggressive Behavior and Mental Well-being
With the rapid proliferation of the Internet and digital entertainment in China, violent video games have become increasingly accessible to adolescents. This trend raises growing public health concerns regarding the psychological and behavioral development of young individuals. Adolescents with limited self-regulation may experience excessive exposure to violent gaming content, which has been associated with heightened risks of aggressive behavior, impaired moral judgment, reduced academic performance, and potential antisocial tendencies. These behaviors not only affect individual well-being but may also contribute to broader social and mental health issues. This study aims to examine the relationship between violent video game exposure and adolescent aggressive behavior from a public health standpoint. Key variables include game market penetration, usage patterns, the intensity of violent content, and adolescents' normative beliefs about aggression. Data were collected using the Video Game Questionnaire (VGQ), the Buss-Perry Aggression Questionnaire (PBAQ), and the Normative Beliefs About Aggression Scale (NOBAGS). The findings are intended to inform early behavioral interventions and preventive strategies that promote adolescent mental health and reduce the public health risks associated with digital violence exposure.
Optimization of Ultrasound-Assisted Deep Eutectic Solvent (DES) Extraction Process for Total Flavonoids from Robinia pseudoacacia Flowers and Evaluation of Their Antioxidant Activity
Objective: To establish a green and efficient extraction process for total flavonoids from Robinia pseudoacacia L. flos using ultrasound-assisted deep eutectic solvents (DESs), optimize the process using response surface methodology, and systematically evaluate their in vitro antioxidant activities, providing experimental evidence for the development and utilization of active components in Robinia pseudoacacia flowers. Methods: Choline chloride was used as the hydrogen bond acceptor (HBA), and 1,2-propanediol, ethylene glycol, and lactic acid were used as hydrogen bond donors (HBD) to prepare three DES systems. Single-factor experiments were conducted to investigate the effects of HBA: HBD molar ratio, water content, liquid-to-solid ratio, ultrasonic time, and temperature on the extraction rate of total flavonoids. The extraction conditions were then optimized using Box-Behnken response surface design. High-performance liquid chromatography (HPLC) was used to determine the content of major flavonoid components (rutin, quercetin, and luteolin). The antioxidant capacity was evaluated by DPPH· and ABTS⁺ free radical scavenging rates. Results: Single-factor analysis showed that the highest extraction rate was achieved when the DES was choline chloride-1,2-propanediol (molar ratio 1:3), water-to-DES volume ratio was 3:1, liquid-to-solid ratio was 35:1 (mL/g), ultrasonic temperature was 65 ℃, and ultrasonic time was 40 min. Response surface optimization indicated that the theoretical extraction rate under these conditions was 4.26%, and the average value of the validation experiment was 4.22%, with an error of less than 1%. HPLC analysis revealed that the contents of rutin, quercetin, and luteolin were 2.06, 1.32, and 0.84 mg/g, respectively. Antioxidant experiments showed that when the extract concentration was 0.4 mg/mL, the scavenging rates of DPPH· and ABTS⁺ were 81.45% and 92.30%, respectively, with no significant difference compared to the vitamin C group (P>0.05). Conclusion: The established DES-ultrasound-assisted extraction method is green, environmentally friendly, and reproducible, significantly improving the extraction rate of flavonoids from Robinia pseudoacacia flowers. The extract has strong antioxidant capacity, providing a scientific basis for its application in the development of natural antioxidants.
Progress in Rehabilitation Treatment of Anterior Cruciate Ligament Rupture in Sports Injuries
Anterior cruciate ligament (ACL) rupture is a high incidence of injury in sports medicine, especially in soccer, basketball and other sports requiring sudden stop and change of direction. The annual incidence rate of high-risk sports population is higher, and the risk of female football players is more prominent due to physiological characteristics. Although surgical techniques continue to mature, the quality of postoperative rehabilitation directly determines the effectiveness of joint function recovery and the success rate of returning to exercise. This article systematically reviews the latest developments in the rehabilitation treatment of ACL rupture, with a focus on the innovation of precision assessment systems, the updating of early rehabilitation concepts, the application of advanced technologies, individualized strategies for special populations, and the development of interdisciplinary collaboration models. Research has found that the dynamic evaluation of integrated vertical jumping tests can effectively identify "pseudo rehabilitation", the integrated medical and nursing technology model can significantly shorten the recovery time of joint range of motion, and the combination of virtual reality and isokinetic training can significantly improve muscle strength and functional scores. These advances are driving the transformation of ACL rehabilitation from a traditional experiential model to a more precise, personalized, and multidimensional direction. This transformation significantly improves the postoperative functional recovery rate and significantly reduces the risk of secondary injury. This article provides evidence-based support for clinical rehabilitation practice, helping to optimize rehabilitation plans and improve patient outcomes.
Recent Advances in the Role of Edible Fungi in Sarcopenia: A Review
Sarcopenia, a degenerative skeletal muscle disease closely related to aging, has become a major threat to the health and quality of life of older adults. With the global trend of population aging, the social and economic problems caused by sarcopenia are becoming increasingly prominent. Currently, pharmacological treatments for sarcopenia are somewhat limited, whereas nutritional interventions have shown potential advantages in combating the condition. This review comprehensively discusses the bioactive components and functional properties of edible fungi and provides a thorough understanding of the severe health issues faced by sarcopenia patients, such as muscle degeneration and functional loss. Although animal experiments and early human studies support the positive effects of edible fungi, large-scale nutritional epidemiology studies in humans are still insufficient, which limits their application in the prevention and treatment of sarcopenia. Therefore, future research, such as randomized controlled trials, is needed to fully understand their effects on muscle health and to provide a solid scientific basis for the prevention and management of sarcopenia.
A Review of the Mechanisms of Tumor Drug Resistance and Clinical Strategies
Cancer treatment is a core challenge in clinical oncology. Despite the continuous advancement of chemotherapy, targeted therapy, and immunotherapy, the emergence of tumor drug resistance remains a key factor leading to treatment failure and worsening patient prognosis. Clinical data indicate that approximately 90% of treatment failures in patients with advanced cancer are directly related to drug resistance. Therefore, systematically analyzing the mechanisms of drug resistance and developing targeted strategies to address them are crucial for improving the efficacy of cancer treatment. This article systematically expounds on the main mechanisms of tumor drug resistance from the perspectives of tumor cell biological characteristics, tumor microenvironment regulation, and epigenetic modifications. These include reduced intracellular drug accumulation, mutations or aberrant expression of drug targets, inactivation of apoptotic pathways, cancer stem cell (CSC)-mediated resistance, and the regulatory role of immunosuppressive cells and cytokines in the tumor microenvironment. Furthermore, based on clinical practice, this article summarizes currently used strategies, such as drug development targeting resistance-associated molecules, chemotherapy regimen optimization and combination therapy, synergistic application of immunotherapy and conventional therapies, personalized treatment plan development, and the clinical translation of resistance monitoring technologies. Research has shown that the development of tumor drug resistance is the result of multiple factors and pathways, and a single strategy is unlikely to effectively reverse drug resistance. However, multi-target, multi-modal combination therapy based on resistance mechanisms, combined with dynamic resistance monitoring technology, can significantly improve treatment outcomes for patients with drug-resistant tumors. This article aims to provide a theoretical basis for clinicians to formulate tumor treatment plans and to guide future research related to drug resistance.
A Study on the Applicability of Catford's Theory of Translation Shifts to Medical Guideline Texts
Medical guideline texts (e.g., clinical practice guidelines, drug package inserts, diagnostic and treatment manuals) are characterized by strong prescriptiveness, high information density, and dual readership orientation (targeting both healthcare professionals and general patients). Their translation must strictly adhere to scientific accuracy while simultaneously accommodating the readability and cultural adaptability of the target language. Guided by Catford's Theory of Translation Shifts, this paper analyzes the practical application of level shifts and category shifts through typical translation examples, based on the stylistic function, terminology system, and communicative context of medical guidelines. It reveals the theoretical significance of Catford's model in resolving issues such as syntactic conflicts, terminology standardization, and cultural defaults in medical guideline translation.
Effects of Traditional Chinese Medicine on Gastrointestinal Dysfunction in Sepsis from Intestinal Flora
Gastrointestinal dysfunction in sepsis is a key link affecting the prognosis, and its occurrence is closely related to intestinal flora disorders. From the perspective of modern medicine, intestinal flora, this paper discusses the preventive and therapeutic effects of traditional Chinese medicine. The article first combed the understanding of gastrointestinal dysfunction of sepsis in traditional Chinese medicine, which belongs to the category of "intestinal obstruction" and "Guange", and the core of pathogenesis is "toxin damaging intestinal collaterals, fu-organ qi obstruction". The key role of intestinal flora imbalance, barrier function damage and immune inflammatory response out of control in morbidity was elaborated. This paper focuses on the synergistic mechanism of traditional Chinese medicine in multi-target regulation of flora structure, repair of intestinal barrier and inhibition of excessive inflammation through purgative, heat-clearing and detoxifying, spleen-invigorating and blood-activating therapy. The analysis shows that the intervention strategy of TCM based on the principle of "holistic concept" and "strengthening the body resistance and eliminating pathogens" is highly consistent with the inherent requirements of regulating "flora-intestine-axis", which provides a unique way of thinking for clinical prevention and treatment.
Exploring the Mechanism of Action of Naringenin in the Treatment of Periodontitis Based on Network Pharmacology Methods
Objective: This study aims to elucidate the potential molecular mechanisms of naringenin in treating periodontitis using network pharmacology, molecular docking, and bioinformatics analysis. Methods: Potential targets of naringenin were predicted using databases such as SwissTargetPrediction and TCMSP. Periodontitis-related genes were retrieved from GeneCards, DisGeNET, and OMIM. Common targets were identified via Venn diagrams, and a protein-protein interaction (PPI) network was constructed using STRING. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed with R. Molecular docking was conducted using AutoDock Vina to evaluate binding affinities between naringenin and core targets. Results: A total of 107 potential targets for naringenin were identified, with 49 overlapping with periodontitis-related genes. Key targets included IL1B, CXCL8, CD44, MMP2, EGFR, and ITGAM. Enrichment analysis revealed involvement in pathways such as HIF-1 signaling, cytokine-cytokine receptor interaction, and ferroptosis regulation. Molecular docking showed strong binding affinities. Conclusion: Naringenin exerts anti-periodontitis effects through multi-target interactions, primarily modulating inflammation, oxidative stress, and ferroptosis. This provides a theoretical basis for its clinical application.
Analysis of Major Treatments for Liver Cancer and Their Prognostic Effects
Liver cancer is a highly prevalent malignancy worldwide. The choice of treatment and its prognostic impact directly impact patients' quality of life and survival. This article, drawing on data from global cancer statistics, Chinese liver cancer diagnosis and treatment guidelines, and several classic clinical studies, systematically reviews the main treatment options for liver cancer, including surgery, local ablation, interventional therapy (such as TACE and TAI), drug therapy (targeted therapy, immunotherapy), and combined treatment. The article also compares the short-term efficacy, long-term survival, and safety of these treatments. Prognostic factors, such as clinical stage, liver function status, and treatment compliance, were analyzed. Prognostic optimization strategies were proposed based on real-world research findings. Results showed that patients with early-stage liver cancer treated with liver resection or liver transplantation had a 5-year survival rate of 60%-70%. For patients in the middle and late stages, TACE combined with targeted therapy extended the median survival to 15-20 months. However, patients with Child-Pugh C liver function generally have a poor prognosis. Studies have shown that personalized treatment plans and a multidisciplinary team (MDT) approach can significantly improve the prognosis of patients with liver cancer, providing a reference for clinical treatment decision-making.
The Predictive Value and Countermeasures of Sarcopenia on the Prognosis of Postoperative Patients
Sarcopenia is a syndrome characterized by a progressive decrease in skeletal muscle mass, strength, and function. In recent years, its significance as an important prognostic indicator in perioperative surgery management has become increasingly prominent. This article aims to explain the value of sarcopenia in predicting postoperative outcomes and propose a comprehensive intervention strategy based on existing evidence to significantly improve the postoperative prognosis of surgical patients, enhancing their quality of life and reducing the burden of medical care.
Study on the Effect of Cadmium Stress on Rice Seed Germinations
This study investigates the effects of cadmium (Cd) stress at different concentrations on rice seed germination and physiological metabolism. The results show that under medium to high Cd concentrations, both the germination rate and germination potential of rice seeds significantly decreased, with a particularly pronounced inhibitory effect on the root system. The research concludes that Cd stress disrupts rice seed germination through a dual mechanism of "inhibiting starch catabolism" and "impeding substance transport." Firstly, it suppresses the activity of α- and β-amylase, reducing the consumption rate of stored substances and cutting off the energy source for germination. Secondly, it induces oxidative stress (SOD and POD activities exhibit a "low-promotion, high-inhibition" response, while MDA content significantly increases), damaging the cell membrane system and severely hindering the transport efficiency of stored substances to the seedlings. This disrupts the energy supply during rice seed germination, leading to growth inhibition. These findings provide theoretical support for mitigating Cd pollution through root system protection and metabolic regulation.
Understanding Multi-Dimensional Attitudes to Influenza Vaccination a Comparative Study of Parents, Teenagers, and Doctors
Influenza vaccination is the most effective preventive strategy against seasonal flu, but vaccine hesitancy still prevents many people from getting it. This qualitative study explored factors shaping attitudes toward influenza vaccination among parents, teenagers, and doctors. 19 semi-structured interviews were conducted with 7 parents, 5 teenagers, and 7 doctors. Open-ended questions were adapted from the World Health Organization’s Vaccine Hesitancy Survey Framework. Transcripts were analyzed using Braun and Clarke’s six-phase thematic analysis within a social-constructivist framework. Two themes emerged: (1) vaccination as a personal decision shaped by perceived limited effectiveness, confidence in self-health, and neglect of collective value; and (2) vaccination as socially influenced by misinformation, fear of side effects, and medical advice. Teenagers were influenced by peers and health misinformation; parents balanced perceived risks and protection; and doctors emphasized evidence and collective health. These findings indicate that vaccine hesitancy is socially embedded. Uneven trust, miscommunication, and fear of discomfort hinder vaccine confidence, while doctor recommendations remain influential but context dependent. Uptake can be enhanced by empathic, straightforward communication that frames protection as a personal advantage and mild side effects as normal. To maintain increased vaccination rates across populations, policymakers should reestablish institutional trust and incorporate customized communication tactics.
Current Applications and Future Perspective of CRISPR/Cas9 Gene Editing in Cancer Therapy
Clustered Regularly Interspaced Short Palindromic Repeats/Clustered Regularly Interspaced Short Palindromic Repeats-associated 9 (CRISPR/Cas9) is one of the most popular gene-editing tools derived from bacterial adaptive immune systems in recent years. Cancer is a complex disease that is related with the accumulation of genetic mutation; it can be caused by physical, chemical, and biological factors and is almost impossible to cure. Due to enabling precise genomic modifications, CRISPR/Cas9 gene editing has revolutionized cancer therapy. Recent studies emphasize its multi-functional role in both gene correction and immune regulation, positioning it as a versatile tool against diverse malignancies. Through comprehensive literature research, analyzing, and discussion, this study explores the mechanisms of utilizing CRISPR/Cas9 gene editing to treat cancer, including traditional application that focuses on the intensity of gene expression and next generation technology that shifts the research subjects to primers and basepairs, the delivery ways, and some immunology-combined therapies. The study also points out the challenges that still need to be solved in the future. Considering safety, we should think about off-target and live-system-caused gene integration. And for validity, we should figure out what kind of cells can be edited, how efficient is the editing process, and how to deliver the system to the target in human’s body. Through numerous propelling clinic trials, we can see that this newly-discovered gene editing method is bringing a brand new revolution in cancer treatment. CRISPR/Cas9 has the transformative potential to bridge the gap between the laboratory research and clinical application, and open a new era of cancer biology.
A Study on the Current Status of Urban-Rural Health Disparities and the Impact of Food Policies
My country exhibits significant health disparities between urban and rural residents, a phenomenon closely related to unbalanced regional economic development, uneven resource allocation, and public policy orientation. Currently, urban residents generally outperform rural residents in terms of life expectancy and chronic disease management, but rural areas face significant challenges in infectious disease prevention and control, maternal and child health care, and access to basic medical services. As a key factor influencing residents' nutritional intake and health outcomes, the design and implementation of food policies profoundly shape urban and rural health patterns. Research has found that the urban-biased food distribution system, subsidy policies, and uneven market regulation exacerbate nutritional imbalances and food safety risks among rural residents. Furthermore, rural nutrition intervention programs have limited coverage and inadequate precision, making it difficult to effectively address health inequalities caused by income constraints and market failures. This article proposes the development of a coordinated urban-rural food policy system: optimizing agricultural product price support and subsidy structures, shifting towards a nutrition-oriented approach; strengthening rural food market regulation and infrastructure development; and integrating community resources to develop nutrition education and affordable healthy food supply programs. Through policy coordination, the nutritional health of rural residents can be significantly improved, the urban-rural health gap can be narrowed, and the Healthy China strategy can be implemented.
Research on the Construction of Microtia Repair Scaffold Based on 3D Bioprinting Technology
Microtia is a congenital auricular hypoplasia, clinically characterized by partial or complete loss of the auricle. This condition not only affects patients' hearing function but also significantly negatively impacts their psychological and social adaptation. Current mainstream treatments include autologous rib cartilage transplantation and implantation of artificial materials, but these are associated with issues such as secondary damage to the donor site, implant exposure, and insufficient morphological fidelity. Recent advances in 3D bioprinting technology have provided a new avenue for constructing highly compatible and biocompatible auricle scaffolds. This study focused on the use of 3D bioprinting technology to fabricate personalized auricle repair scaffolds and systematically evaluated their potential in terms of morphological fidelity, mechanical properties, and biological function. The research method primarily involved: first, 3D reconstruction using patient CT imaging data accurately reproduced the ear anatomy; then, using polycaprolactone (PEL) and gelatin-methacrylamide (GelMA) as the base materials, a composite scaffold with a hierarchical structure was fabricated using a combination of fused deposition modeling (FDM) and photopolymerization techniques; and then, using an in vitro chondrocyte co-culture system, the scaffold's cytocompatibility and chondrogenic efficacy were systematically evaluated. Experimental results show that the prepared scaffold is highly consistent with the complex curved surface of the ear in terms of morphology, has mechanical properties close to those of natural ear cartilage, presents a uniform and interconnected porous structure inside, and its degradation behavior can also be effectively controlled. Cell experiments showed that the surface of the scaffold is conducive to cell adhesion and extension, cell proliferation activity is significantly enhanced, and it can promote the synthesis and deposition of key extracellular matrix components such as collagen fibers and glycosaminoglycans. The above results indicate that the scaffold has good application potential in the field of cartilage regeneration. In summary, the strategy of constructing personalized auricle scaffolds based on 3D bioprinting technology provides a promising new approach for the functional repair of microtia.
Study on the Association Between Economic Burden of Cancer Treatment and Social Health Inequality
This study investigates the correlation between cancer treatment costs and social health inequality. Through integrated analysis of hospital records and survey data, combined with regression modeling and correlation analysis, we demonstrate that socioeconomic disparities significantly influence treatment affordability. Economically disadvantaged populations face higher financial burdens, while educational limitations hinder patients' ability to make informed treatment decisions. Geographically, disparities in healthcare resources and insurance coverage between urban-rural and regional areas disproportionately burden patients in rural and economically underdeveloped regions. These findings provide critical insights for reducing cancer treatment costs and advancing social health equity.
Technical Mechanism and Clinical Prospects of Antigen Protein Chip in Early Detection of Cancer
As the global cancer burden grows, early cancer detection gains importance. This paper explores the application of antigen protein chip technology in early cancer detection. Offering high - throughput, high - sensitivity, and high - specificity simultaneous detection of multiple tumor - related antigens, the technology improves detection accuracy. For instance, multi - protein combined detection raises lung cancer detection sensitivity from 40% to 70% and enables personalized detection. However, high - preparation costs and limited sample size restrict its large - scale clinical application. Its application can boost early - screening efficiency, cut medical costs, and optimize resource allocation. In the future, with technological optimization and cost reduction, it is expected to be widely used in early cancer detection, chronic disease screening, and health management, promoting a medical - mode shift from disease treatment to health management.
The Role of Epigenetic Factors in Cancer Drug Resistance
Cancer is one of the major global health threats. In cancer treatment, the development of drug resistance and tumor recurrence are important clinical challenges. Epigenetic regulation is closely associated with the occurrence and progression of cancer, and many recent studies have also shown that abnormal epigenetic regulation is widely linked to cancer drug resistance. This article reviews the impact of various abnormal epigenetic modifications on cancer drug resistance and discusses the potential of combining epigenetic drugs with existing cancer treatment methods to overcome cancer drug resistance.
Design Strategies and Mechanisms of Action of Small Molecule Drugs for Cancer Treatment
Global cancer incidence continues to rise. According to the World Health Organization in 2022, there will be over 20 million new cancer cases and over 10 million deaths worldwide. Cancer has become a major public health threat to human health. Although surgery, chemotherapy, radiotherapy, and immunotherapy are currently mainstream treatments, they have significant limitations: surgery struggles to eliminate micrometastases and is only suitable for early-stage, localized tumors; chemotherapy drugs such as cisplatin are prone to severe side effects such as bone marrow suppression and nausea and vomiting, and cannot accurately distinguish between tumors and normal cells; radiotherapy relies on radiation to kill tumors, but it can easily damage the skin, mucous membranes, and internal organs in the irradiated area; and immunotherapies such as PD-1 inhibitors, while able to activate the body's immune response, only produce sustained efficacy in 20%-30% of patients and carry the risk of immune-related adverse reactions. Small molecule drugs (molecular weight <1000 Daltons) have become a core force in cancer treatment due to their unique advantages: they are easily absorbed by the intestine after oral administration and have strong tissue penetration, allowing them to directly reach tumor tissue and penetrate cell membranes to act on intracellular targets. Their relatively simple chemical structure allows for mass production through chemical synthesis, resulting in significantly lower production costs than large molecule drugs. Currently, over 150 small molecule anticancer drugs have been approved for marketing worldwide, covering a variety of cancer types, including lung cancer, leukemia, and breast cancer. Imatinib, among others, has increased the five-year survival rate of patients with chronic myeloid leukemia from 30% to over 90%, marking a milestone in targeted cancer therapy. This article systematically reviews the definition and characteristics of small molecule drugs, deeply analyzes design strategies based on target structure, biological activity, and innovative directions, and explains their mechanisms of action in inhibiting tumor cell proliferation, inducing tumor cell apoptosis, blocking tumor angiogenesis, and modulating the tumor immune microenvironment. It also summarizes the current challenges in R&D, drawing on the technical support system. This paper provides theoretical references for the R&D optimization and clinical application of small molecule drugs, and contributes to the advancement of precision cancer treatment.
Mechanisms of the Impact of Sleep Loss on Obesity and Health Management Recommendations
The accelerated pace of modern life and the ever-increasing compression of sleep time have become a significant public health issue. Interestingly, rising obesity rates appear to coincide with sleep deprivation. A growing number of studies have found that insufficient sleep not only makes us tired but can also subtly alter our bodies, making us more susceptible to weight gain. What's going on here? We've observed that insufficient sleep disrupts the body's hunger signaling system—a decrease in leptin levels and an increase in ghrelin levels. This results in a constant craving for food, particularly for high-fat and high-sugar snacks. Simultaneously, the body's stress response system is activated, with increased production of stress hormones like cortisol. This interferes with the proper functioning of insulin, impairing the body's ability to process sugar and leading to increased fat accumulation, particularly visceral fat, which is more harmful to health. The body's internal clock is also disrupted, causing metabolic genes that should be active at specific times to become unresponsive, disrupting the overall rhythm of energy metabolism. Behaviorally, poor sleep can lead to increased inactivity, increased sitting time, and a decreased desire for exercise. Combined with decreased self-control, this can lead to increased choices of unhealthy foods. Therefore, to effectively manage weight and prevent obesity, simply focusing on "controlling your diet and moving your legs" is not enough; "good sleep" must be a key component. If you want to manage your weight, getting a good night's sleep is fundamental. We all need to prioritize sleep, striving for a full 7-9 hours per night, avoiding fluctuating between early and late sleep, limiting phone use before bed, and ensuring a comfortable bedroom. When treating overweight patients, doctors shouldn't just focus on diet and exercise; they should also ask about sleep quality and bedtime habits, providing assistance where necessary. In society, we should change old norms that force people to work late, and schools should ring their bells less early in the morning to allow children to stay in bed longer. Only by addressing these issues together can we truly address the weight gain associated with insufficient sleep.
Gout Does Not Causally Increase the Risk of Endometrial Cancer: Evidence from Mendelian Randomization
Background: Gout is a prevalent condition associated with chronic inflammation and metabolic dysregulation, both of which are known risk factors for various malignancies. However, the potential causal relationship between gout and endometrial cancer has not been systematically explored. Methods: A two-sample Mendelian randomization (MR) analysis was conducted using genome-wide association study (GWAS) summary statistics to evaluate the potential causal effect of genetically predicted gout on the risk of endometrial cancer. Genetic variants strongly associated with gout were selected as instrumental variables. The inverse variance weighted (IVW) method was used for the primary analysis, supplemented by MR-Egger and weighted median approaches. Sensitivity analyses included tests for pleiotropy, heterogeneity, and leave-one-out stability. Results: The MR analysis revealed no significant causal effect of gout on the risk of developing endometrial cancer (IVW OR = 1.015, 95% CI: 0.957–1.077, P = 0.614). Sensitivity analyses indicated no evidence of pleiotropy or heterogeneity, and the leave-one-out analysis confirmed the robustness of the results. Conclusion: This MR analysis found no evidence supporting a causal effect of gout on the risk of endometrial cancer. These results suggest that genetic predisposition to gout does not significantly influence the likelihood of developing endometrial cancer. Further studies in diverse populations are needed to confirm these findings and explore potential shared mechanisms linking metabolic disorders to cancer development.
Factors Influencing Rehabilitation Behavior in Stroke Patients
Background: Stroke has high incidence and disability rates; rehabilitation is key to reducing disability and improving quality of life. This study identifies factors influencing rehabilitation behavior, supporting the development of personalized plans. Methods: This study identified stroke rehabilitation factors using the CFIR and created a questionnaire for follow-up analysis. Results: Qualitative interviews identified multiple barriers and facilitators across CFIR domains: patients (13 each, 5 domains), caregivers (14 barriers, 15 facilitators, 5 domains), and healthcare workers (14 barriers, 12 facilitators, 4–5 domains).Factor analyses of the questionnaires revealed levels of pain or discomfort (P=0.017), annoyance with daily activities (P=0.007), annoyance with social interaction (P=0.015), understanding of healthcare staff's explanations of the condition (P=0.046), accurate understanding of post-stroke rehabilitation (P=0.024), and the individual's sense of identification with the organization (P=0.003). (P=0.003) were associated with rehabilitation behavior. The difference was statistically significant (P<0.05). Conclusions: This study used interviews and questionnaires to identify key factors influencing stroke patients’ and caregivers’ rehabilitation behaviors, highlighting links between behavior, context, and individual traits to support personalized rehabilitation.
Research Status and Prospect of 3D Printing Technology in Dental Prosthetic Materials
The Application of 3D Printing Technology (Additive Manufacturing) in the Field of Dental Prosthetics Is Rapidly Expanding. Its high precision, personalization, and efficient production make it an important part of digital dentistry. This article reviews the current research status of 3D printing technology in dental prosthetic materials (such as resins, ceramics, metals, and biocompatible materials), discusses its applications in crowns, fixed bridges, removable partial dentures, implant guides, and maxillofacial prosthetics, and analyzes the challenges faced by current technologies and future development directions to provide references for clinical and research purposes.
This study provides an in-depth analysis of the HiAP concept, positioning it as an innovative strategy that incorporates health considerations into the entire policy-making process, emphasizing its potential to enhance public health standards. It also interprets the ‘Healthy China Initiative’, clarifying its goal of putting people's health at the center and promoting comprehensive, full-cycle health services. The evolution from HiAP to health integration follows a logical progression from conceptual dissemination to practical implementation. However, this process faces challenges such as interdepartmental coordination difficulties, complex health influencing factors, and policy implementation obstacles. To address these challenges, strategies are proposed including strengthening interdepartmental collaboration mechanisms, enhancing capacity to respond to health influencing factors, and improving policy implementation safeguards. This research aims to provide theoretical and practical guidance for advancing Healthy China initiatives, contributing to achieving national health goals and elevating the country's overall health governance capabilities.
Quality Assurance and Professional Formation in Graduate Medical Education: Evidence from Internal Medicine Sector
This study examines quality assurance mechanisms and professional formation processes in graduate medical education within Chinese healthcare and medical education institutions. Using panel data from 2018 to 2024, we analyze 7,890 firm-year observations from CNRDS and CSMAR databases. The research investigates how institutional quality assurance frameworks influence professional development outcomes. Results demonstrate significant positive relationships between structured quality assurance programs and professional formation indicators. Healthcare institutions with comprehensive quality frameworks show 23% higher professional development scores. Medical education institutions exhibit stronger correlations between quality metrics and graduate outcomes. The study reveals heterogeneous effects across institution types and geographical regions. Mechanism analysis indicates that quality assurance operates through enhanced supervision, standardized curricula, and performance monitoring. These findings contribute to understanding professional education effectiveness in healthcare contexts. Policy implications suggest targeted quality enhancement programs can improve medical education outcomes.
Publicity and Research on Adolescent Scoliosis
The incidence of adolescent scoliosis (AIS) in China has been increasing year by year and has become an important issue threatening the health of adolescents. This study systematically reviewed the definition, classification and pathological mechanism of adolescent scoliosis, revealing the significant influence of factors such as genetics, growth and development, and lifestyle on its occurrence. Survey data indicates that the public's awareness of diseases is insufficient, treatment costs are high, and the coverage rate of screening is low. It is urgent to strengthen health education and early screening work. Psychological intervention strategies emphasize the importance of family and social support. Building a multi-party collaborative system can enhance the prevention and treatment effect.
Positive Psychology and Mental Health Education
Against the backdrop of accelerating social transformation and rising competitive pressures, mental health issues among adolescents and college students have become increasingly prominent. The traditional mental health education model, which focuses on problem correction, has gradually exposed bottlenecks of insufficient effectiveness. As a new psychological paradigm emerging at the end of the 20th century, positive psychology shifts its research focus to individuals' positive psychological qualities, intrinsic potential, and subjective well-being, providing important theoretical support and path guidance for the conceptual renewal and practical transformation of mental health education. By systematically reviewing relevant theoretical and practical studies, this paper explores the application value, existing achievements, and challenges of positive psychology in mental health education, aiming to provide references for in-depth research and educational practice in this field.
Research Progress on Antimicrobial Surface Modification Materials for Dental Implants
Peri-implantitis is one of the main reasons for the failure of dental implants. Traditional implant surfaces lack antimicrobial properties and are prone to bacterial infections. In recent years, antimicrobial surface modification technologies for implants have become a research hotspot. These technologies endow implants with antimicrobial functions through physical, chemical, or biological methods to improve long-term success rates. This paper reviews the main strategies for antimicrobial surface modification of implants (such as antimicrobial coatings, nanostructural modifications, ion doping, and bioactive molecule loading), analyzes the advantages and disadvantages of different methods, and explores future development directions to provide a theoretical basis for the design of clinical implants.
A Molecular Mechanism-Based Approach: Differences in the Roles of Berberine, Quercetin and Baicalin in the Treatment of Breast Cancer
Breast cancer is considered one of the most prevalent types of malignant tumours among women worldwide, and recent academic studies have revealed that natural products highlight a key role in the intervention and treatment of breast cancer. The present study focused on three typical natural active compounds, berberine, quercetin and baicalin. It investigates their molecular pathways and functional heterogeneity in the field of breast cancer therapy, further compares the characteristics of the molecular mechanisms of each of the three compounds and their differences in the treatment of breast cancer, and at the same time deeply discusses their potential application value in combination therapy strategies as well as their future development trends in the field of breast cancer therapy.