Triangular Lipid Strategy for Neurodevelopment: Formulation Engineering, Nanocarrier Performance, and Evidence Base of a BCLC Acer truncatum Seed Oil-Phosphatidylserine-Linseed Oil Composite

Abstract

We integrated formulation-characterization data, process-optimization records, nanocarrier-performance testing, storage-stability observations, and peer-reviewed literature to evaluate a BCLC lipid composite built around Acer truncatum seed oil, phosphatidylserine (PS), and linseed oil. The formulation dataset showed that the most favorable preparation window was obtained at an oil-phase temperature of 45 C, aqueous-phase pH 7.4, 4 min of high-speed shearing, and four high-pressure homogenization cycles. Under these conditions, the hybrid nanocarrier exhibited an average particle size of about 148 nm, a polydispersity index of 0.14, a zeta potential of -35 mV, encapsulation efficiencies of 93% for Acer truncatum seed oil, 91% for PS, and 92% for DHA phospholipid, and limited particle-size changes in simulated gastric and intestinal fluids (5% and 7%, respectively). During 28 days of storage, low-temperature light-protected conditions produced the slowest rise in peroxide and acid values. Published evidence aligned with this formulation logic: nervonic acid has been linked to myelin biology, Acer truncatum seed oil has shown cognition-related benefits in rodent models, PS supports membrane signaling and has demonstrated clinical signals in pediatric cognition studies, and omega-3 fatty-acid sufficiency remains relevant to neurodevelopmental outcomes. Taken together, the current data support a triangular lipid strategy in which myelin-oriented lipids, membrane phospholipids, and omega-lipid carrier support are organized within a phospholipid-assisted nanocarrier.