Technical Mechanism and Clinical Prospects of Antigen Protein Chip in Early Detection of Cancer

Shengyuan Qin; Shuolei Zhao; Xi Chen; Xiaofang Lu; Ninggui Duan

doi:10.62051/ijphmr.v5n1.02

Authors

Shengyuan Qin
Shuolei Zhao
Xi Chen
Xiaofang Lu
Ninggui Duan

DOI:

https://doi.org/10.62051/ijphmr.v5n1.02

Keywords:

Antigen Protein, Cancer, Detection Technology, Multi - protein Combined Detection

Abstract

As the global cancer burden grows, early cancer detection gains importance. This paper explores the application of antigen protein chip technology in early cancer detection. Offering high - throughput, high - sensitivity, and high - specificity simultaneous detection of multiple tumor - related antigens, the technology improves detection accuracy. For instance, multi - protein combined detection raises lung cancer detection sensitivity from 40% to 70% and enables personalized detection. However, high - preparation costs and limited sample size restrict its large - scale clinical application. Its application can boost early - screening efficiency, cut medical costs, and optimize resource allocation. In the future, with technological optimization and cost reduction, it is expected to be widely used in early cancer detection, chronic disease screening, and health management, promoting a medical - mode shift from disease treatment to health management.

References

[1] Huang Y. Application Value of Serum Alpha-Fetoprotein, Carcinoembryonic Antigen, Carbohydrate Antigen 199 and Carbohydrate Antigen 125 in the Diagnosis of Primary Liver Cancer [J]. Primary Medical Forum, 2025, 29(24): 36 - 38. DOI: 10.19435/j.1672 - 1721.2025.24.011.

[2] Shi Z J, Gu F, Xu Q. Correlation Analysis of Preoperative Serum Carcinoembryonic Antigen and Cytokeratin 19 Fragment Antigen 21 - 1 Levels with Lymph Node Involvement in Patients with Pulmonary Adenocarcinoma [J]. Cancer Progress, 2025, 23(12): 1473 - 1476. DOI: CNKI: SUN: AZJZ.0.2025 - 12 - 027.

[3] Li P F, Yao L, Niu J J. Effect of Bicalutamide on Clinical Efficacy and Serum Heat Shock Protein 90α, Prostate - Specific Antigen Levels in Patients after Radical Prostatectomy for Prostate Cancer [J]. Basic & Clinical Oncology, 2025, 38(03): 371 - 373. DOI: CNKI: SUN: HLZL.0.2025 - 03 - 018.

[4] Tan J L. Clinical Value of Low - Dose CT Iterative Reconstruction Technology in Early Lung Cancer Screening [J]. Journal of Practical Medical Imaging, 2023, 24(02): 135 - 138. DOI: 10.16106/j.cnki.cn14 - 1281/r.2023.02.015.

[5] Chen F, Wang W, Gu D Y, et al. Application of Modified Polydimethylsiloxane (iPDMS) Protein Chip in Screening of Tumor - Related Antigen Autoantibodies [J]. Chinese Journal of Bioengineering, 2021, 37(11): 4075 - 4082. DOI: 10.13345/j.cjb.210017.

[6] Li Z M, Wang Y, Han H T, et al. Simultaneous Detection of Multiple Antibiotics in Feed by Visual Protein Chip [J]. Journal of Food Safety and Quality, 2020, 11(18): 6687 - 6693. DOI: 10.19812/j.cnki.jfsq11 - 5956/ts.2020.18.072.

[7] Sun G Y. Evaluation of the Diagnostic Value of Esophageal Squamous Cell Carcinoma - Related Antigens and Their Autoantibodies Screened by Protein Chip and GEO [D]. Zhengzhou University, 2020. DOI: 10.27466/d.cnki.gzzdu.2020.004009.

[8] Gu X X, Wu X J, Zhu X J, et al. Advances in Circulating Tumor Cell Detection Technology and Its Clinical Applications [J]. Journal of Gannan Medical University, 2019, 39(11): 1097 - 1102.

[9] Li Z M, Wang Y, Leng H X, et al. Simultaneous Detection of Clenbuterol and Ractopamine Residues in Food by Protein Chip [J]. Journal of Analysis and Testing, 2019, 38(08): 913 - 919.

[10] Wang W, Zhang L, Li Z M. Detection of Chloramphenicol Residues in Honey Samples by Visual Protein Chip [J]. Food Science and Technology, 2019, 44(05): 323 - 328. DOI: 10.13684/j.cnki.spkj.2019.05.059.

[11] Scientists Develop New Detection Technology for Early Diagnosis of Cancer and Diabetes [J]. Chinese Journal of Clinical Oncology and Rehabilitation, 2019, 26(02): 219. DOI: CNKI: SUN: ZGZK.0.2019 - 02 - 053.

[12] Wang M Z, Luo L, Cai X S. Preparation of Recombinant Endometrial Antigen and Its Application in Protein Chip Detection [J]. Journal of Reproductive Medicine, 2018, 27(07): 677 - 681. DOI: CNKI: SUN: SZYX.0.2018 - 07 - 015.

[13] Wang S, Haishan Zeng. Real - Time Raman Spectroscopy and Its Application in Early Clinical Cancer Detection [J]. Chinese Journal of Lasers, 2018, 45(02): 41 - 55. DOI: CNKI:SUN:JJZZ.0.2018 - 02 - 003.

[14] Zhang T M, Li B L. Advances in Circulating Tumor Cell Detection Technology [J]. Chinese Journal of Diagnostic Medicine (Electronic Edition), 2017, 5(01): 62 - 66. DOI: CNKI: SUN: ZDDZ.0.2017 - 01 - 018.

[15] Huang Y X, Bao Y L, Li Y X. Advances in Immunoinformatics Methods for Antigen Epitope Prediction [J]. Chinese Journal of Immunology, 2008, (09): 857 - 861. DOI: CNKI:SUN:ZMXZ.0.2008 - 09 - 030.