A Molecular Mechanism-Based Approach: Differences in the Roles of Berberine, Quercetin and Baicalin in the Treatment of Breast Cancer

Yingru Zhou

doi:10.62051/ijphmr.v4n2.02

Authors

Yingru Zhou

DOI:

https://doi.org/10.62051/ijphmr.v4n2.02

Keywords:

Breast cancer, Berberine, Quercetin, Baicalin, Signalling pathway, Molecular mechanism

Abstract

Breast cancer is considered one of the most prevalent types of malignant tumours among women worldwide, and recent academic studies have revealed that natural products highlight a key role in the intervention and treatment of breast cancer. The present study focused on three typical natural active compounds, berberine, quercetin and baicalin. It investigates their molecular pathways and functional heterogeneity in the field of breast cancer therapy, further compares the characteristics of the molecular mechanisms of each of the three compounds and their differences in the treatment of breast cancer, and at the same time deeply discusses their potential application value in combination therapy strategies as well as their future development trends in the field of breast cancer therapy.

References

[1] Jiang, S. (2023). Construction of a prognostic risk model for breast cancer aging-related genes based on TCGA database. Gannan Medical College. https://doi.org/10.27959/d.cnki.ggnyx.2023.000101

[2] Zhao, J.-F., Ma, R., Cao, J., et al. (2023). Regulation of stemness expression in breast cancer stem cells by peroxisome proliferator-activated receptor gamma coactivator 1β. Chinese Tissue Engineering Research, 27(01), 59-65.

[3] Zhao, J., & Liu, Y. (2024). Clinical significance of PIK3CA mutation in breast cancer and its detection research progress. Journal of Clinical and Experimental Pathology, 40(9), 973-978.

[4] Mou, C., Pan, W., & Wang, J. (2019). Effect of quercetin modulation of EGFR/AKT/mTOR signalling pathway on the process of proliferation and apoptosis of human breast cancerous cell line T47D. Journal of Clinical and Experimental Medicine, 18(14), 1460-1464.

[5] Li, Y., & Guo, C. (2002). Progress of quercetin metabolism. Advances in Physiological Sciences, 33(1), 53-55.

[6] Han, H., Liu, H., Zhao, Y., & Wang, S. (2025). Exploration of the mechanism of action of quercetin against colorectal cancer through p53 signalling pathway supported by evidence from network pharmacology and experimental validation. Shandong Science, 38(1), 32-43.

[7] Zhao, J.-F., Ma, R., Cao, J., et al. (2023). Regulation of stemness expression in breast cancer stem cells by peroxisome proliferator-activated receptor gamma coactivator 1β. Chinese Tissue Engineering Research, 27(01), 59-65.

[8] Zhao, Y. (2023). Network-based pharmacological study on the effect of Tongjiao and Xuebao Tang on breast cancer cells and its mechanism. Qinghai University. https://doi.org/10.27740/d.cnki.gqhdx.2023.000900

[9] Deng, X., Ruan, H., Li, L., et al. (2024). The role of aerobic glycolysis in breast cancer and the progress of Chinese medicine intervention. Chinese Journal of Experimental Formulas, 30(13), 219-229.

[10] Gao, J., Wu, X., Jiang, Z., & Wang, G. (2018). Role of tumour-associated macrophage polarization in microenvironment on breast cancer progression. Traffic Medicine, 32(3), 205-211.

[11] Qin, T., Yang, Y., Yin, M., Yang, B., Jin, R., Shi, Y., Huang, J., Xu, S. (2024). Effects of berberine on proliferation, migration and apoptosis of triple-negative breast cancer cells MDA-MB-231. Journal of Guizhou Medical University, 49(2), 179-184.

[12] Yang, L. (2020). Quercetin increases the sensitivity of PC-3 cells to paclitaxel and reverses their drug resistance. Kunming Medical University. https://doi.org/10.27202/d.cnki.gkmyc.2020.000267

[13] Gan, L., Xiong, Z., Yang, H., et al. (2021). Apoptotic effect and mechanism of quercetin on breast cancer MCF-7 and MDA-MB-435 cells. Advances in Modern Biomedicine, 21(19), 3638-3644.

[14] Zhao, L., Shi, Z., Hu, Y., & Huang, C. (2024). Exploring the molecular mechanism of quercetin intervention in breast cancer based on network pharmacology and cellular experiments. *Journal of Shenyang Pharmaceutical University, 41(7).

[15] Han, H., Liu, H., Zhao, Y., & Wang, S. (2025). Exploration of the mechanism of action of quercetin against colorectal cancer through p53 signalling pathway supported by evidence from network pharmacology and experimental validation. Shandong Science, 38(1), 32-43.

[16] Hou, Y. (2023). Research on the chemical constituents of two Chinese herbal medicines and their assembled functional activities based on supramolecular structure. Peking Union Medical College. https://doi.org/10.27648/d.cnki.gzxhu.2023.000506

[17] Zhao, Y. (2023). Network-based pharmacological study on the effect of Tongjiao and Xuebao Tang on breast cancer cells and its mechanism. Qinghai University. https://doi.org/10.27740/d.cnki.gqhdx.2023.000900

[18] Li, Y. (2024). Research on the function of plant-derived extracts in inhibiting breast cancer. Henan Agricultural University. https://doi.org/10.27117/d.cnki.ghenu.2024.000030

[19] Liu, Q., Ning, C., Yang, J., & Yue, X. (2020). Relationship of miR-590-5p with signalling and transcriptional activator 3 targeting and its effect on growth and metastatic ability of retinoblastoma Y-79 cells. Chinese Journal of Biological Products, 33(6), 640-647.

[20] Zhao, Y. (2023). Network-based pharmacological study on the effect of Tongjiao and Xuebao Tang on breast cancer cells and its mechanism. Qinghai University. https://doi.org/10.27740/d.cnki.gqhdx.2023.000900

[21] Tang, Y. (2023). Network pharmacological study on the effect of split formula of Haifu yuyuxu Tang on tumour metastasis. North China University of Science and Technology. https://doi.org/10.27108/d.cnki.ghelu.2023.000937

[22] Chen, X., & Li, H. (2024). Application effect and research progress of berberine in regulating Bcl-2/Bax signalling pathway to induce apoptosis. Pharmaceutical Biotechnology, 31(02), 211-215.

[23] Li, Y., et al. (2021). Berberine induces apoptosis and cell cycle arrest in estrogen receptor-positive breast cancer cells via downregulation of HER2/ERα signaling. Oncology Reports, 45(3), 1123-1134.

[24] Liu, M., Wu, K., & Zhao, X. (2005). Effect of quercetin combined with octreotide on the proliferation of human breast cancer cell line MDA-MB-231. China Cancer Clinics, 32(7), 404-406.

[25] Li, Y. (2024). Research on the function of plant-derived extracts in inhibiting breast cancer. Henan Agricultural University. https://doi.org/10.27117/d.cnki.ghenu.2024.000030