Effects of Artemisia Selengensis Dietary Fiber on the Regulation of Blood Glucose and Lipids and Intestinal Flora in Diabetic Mice

Abstract

The aim of this study was to investigate the regulation effect of soluble dietary fiber from Artemisia selengensis on blood glucose and lipid in diabetic mice, and its effect on intestinal flora. SPF grade C57BL/6 mice were selected, blank group was fed basic diet, and other mice were fed high-sugar and high-fat diet for 8 weeks, and then intraperitoneally injected streptozotocin (STZ) solution to establish a diabetic mouse model. After successful modeling, the mice were randomly divided into model control group and Artemisia selengensis fiber group. The blank group was fed the basic diet, the model control group was fed the high-sugar and high-fat diet, and the Artemisia selengensis cellulose group was fed the high-sugar and high-fat diet containing 5.0% Artemisia selengensis cellulose for 4 consecutive weeks. After the feeding, blood glucose and lipid related indexes and intestinal flora composition were detected. The results showed that Artemisia selengensis cellulose could reduce fasting blood glucose, alleviate insulin resistance and improve dyslipidemia in diabetic mice. In addition, Artemisia selengensis cellulose can down-regulate the relative abundance of Firmicutes, Rikenellaceae and Lachnospiraceae, up-regulate the relative abundance of Bacteroidotas and decrease the F/B value. Artemisia selengensis cellulose can effectively improve the blood glucose and lipid levels of diabetic mice, and the mechanism may be achieved by regulating the composition of intestinal flora.