Molecular Biology and Genetics Research on Schizophrenia

Chongwei Shi

doi:10.62051/ijphmr.v2n3.04

Authors

Chongwei Shi

DOI:

https://doi.org/10.62051/ijphmr.v2n3.04

Keywords:

Schizophrenia, Molecular Biology, Genetics, Genomics, Gene-Environment Interaction

Abstract

Schizophrenia is a severe mental disorder characterized by a complex etiology involving genetic, environmental, and neurobiological factors. Recent advances in molecular biology and genetics have provided crucial insights into the pathogenesis of schizophrenia. This paper reviews the fundamental concepts and etiological theories of schizophrenia, with a detailed examination of the applications of molecular biology and genetics in schizophrenia research, particularly focusing on the latest developments in genomics and genetic susceptibility studies. By analyzing the functions of known relevant genes and exploring gene-environment interactions, this paper reveals the complex molecular mechanisms underlying schizophrenia and discusses future research directions. Our research indicates that integrating modern molecular biology techniques and genetic methods will aid in early diagnosis and precise treatment of schizophrenia, advancing clinical applications and optimizing public health strategies.

References

[1] Indonesia Schizophrenia Consortium, et al. "Mapping genomic loci implicates genes and synaptic biology in schizophrenia." Nature 604.7906 (2022): 502-508.

[2] Kato, Hidekazu, et al. "The genetic architecture of schizophrenia: review of large-scale genetic studies." Journal of Human Genetics 68.3 (2023): 175-182.

[3] Farsi, Zohreh, and Morgan Sheng. "Molecular mechanisms of schizophrenia: Insights from human genetics." Current Opinion in Neurobiology 81 (2023): 102731.

[4] Mealer, Robert G., et al. "Glycobiology and schizophrenia: a biological hypothesis emerging from genomic research." Molecular Psychiatry 25.12 (2020): 3129-3139.

[5] Tiihonen, Jari, et al. "Molecular signaling pathways underlying schizophrenia." Schizophrenia Research 232 (2021): 33-41.

[6] Nakamura, Takumi, and Atsushi Takata. "The molecular pathology of schizophrenia: An overview of existing knowledge and new directions for future research." Molecular Psychiatry 28.5 (2023): 1868-1889.

[7] Trifu, Simona Corina, et al. "Genetics of schizophrenia." Experimental and therapeutic medicine 20.4 (2020): 3462-3468.

[8] McCutcheon, Robert A., Tiago Reis Marques, and Oliver D. Howes. "Schizophrenia—an overview." JAMA psychiatry 77.2 (2020): 201-210.