Evaluating the Impact of Enhanced Recovery After Surgery (ERAS) on Postoperative Outcomes in Pancreatic Cancer Patients: A Historical Control Study

Authors

  • Jie Wang
  • Cyrelle D. Agunod

DOI:

https://doi.org/10.62051/ijphmr.v2n2.04

Keywords:

Enhanced Recovery After Surgery (ERAS), Pancreatic cancer, Postoperative outcomes, Rehabilitation, Perioperative care

Abstract

Objective: This study evaluates the impact of the Enhanced Recovery After Surgery (ERAS) program on postoperative outcomes in patients undergoing pancreatic cancer surgery. It compares traditional perioperative care with ERAS-based interventions, focusing on key rehabilitation indicators such as postoperative intestinal function recovery, length of hospital stays, medical costs, and the incidence of complications. Methods: A total of 74 patients were studied, with 37 receiving traditional perioperative care and 37 managed under the ERAS protocol. Data collection included intraoperative indicators such as operation time, fluid input, blood loss, and postoperative recovery measures like first ambulation, pain scores, and complications. Results: The ERAS group demonstrated significantly faster recovery of gastrointestinal function, earlier mobilization, and reduced postoperative pain within the first 12 hours compared to the control group (p<0.05). The incidence of postoperative complications was lower in the ERAS group (13.51% vs. 37.84%, p=0.0166). Furthermore, the ERAS protocol led to a shorter length of hospital stay and lower total medical costs (p<0.0001). Conclusion: The implementation of the ERAS protocol for pancreatic cancer surgery significantly improves recovery outcomes, reduces complications, and lowers healthcare costs. These findings support the broader adoption of ERAS protocols in pancreatic cancer management to optimize clinical and economic outcomes.

References

[1] 2023 Alzheimer’s disease facts and figures. (2023). Alzheimer S & Dementia, 19(4), 1598–1695. https://doi.org/10.1002/alz.13016

[2] Bansal, T., Sharan, A. D., & Garg, B. (2022). Enhanced recovery after surgery (ERAS) protocol in spine surgery. Journal of Clinical Orthopaedics and Trauma, 31, 101944. https://doi.org/10.1016/j.jcot.2022.101944

[3] Galvin, R., Chung, C., Dziakowiec, O., & Sen, S. (2020). Barriers to Clinical Trial Enrollment in Patients With Pancreatic Adenocarcinoma Eligible for Early-Phase Clinical Trials. ONCOLOGY, 3410, 407–412. https://doi.org/10.46883/onc.2020.3410.0407

[4] Gianotti, L., Besselink, M. G., Sandini, M., Hackert, T., Conlon, K., Gerritsen, A., Griffin, O., Fingerhut, A., Probst, P., Hilal, M. A., Marchegiani, G., Nappo, G., Zerbi, A., Amodio, A., Perinel, J., Adham, M., Raimondo, M., Asbun, H. J., Sato, A., . . . Bassi, C. (2018). Nutritional support and therapy in pancreatic surgery: A position paper of the International Study Group on Pancreatic Surgery (ISGPS). Surgery, 164(5), 1035–1048. https://doi.org/10.1016/j.surg.2018.05.040

[5] Irani, J. L., Hedrick, T. L., Miller, T. E., Lee, L., Steinhagen, E., Shogan, B. D., Goldberg, J. E., Feingold, D. L., Lightner, A. L., & Paquette, I. M. (2022a). Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons. Diseases of the Colon & Rectum, 66(1), 15–40. https://doi.org/10.1097/dcr.0000000000002650

[6] Irani, J. L., Hedrick, T. L., Miller, T. E., Lee, L., Steinhagen, E., Shogan, B. D., Goldberg, J. E., Feingold, D. L., Lightner, A. L., & Paquette, I. M. (2022b). Clinical practice guidelines for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons. Surgical Endoscopy, 37(1), 5–30. https://doi.org/10.1007/s00464-022-09758-x

[7] Isselbacher, E. M., Preventza, O., Black, J. H., Augoustides, J. G., Beck, A. W., Bolen, M. A., Braverman, A. C., Bray, B. E., Brown-Zimmerman, M. M., Chen, E. P., Collins, T. J., DeAnda, A., Fanola, C. L., Girardi, L. N., Hicks, C. W., Hui, D. S., Jones, W. S., Kalahasti, V., Kim, K. M., . . . Volgman, A. S. (2022). 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation, 146(24). https://doi.org/10.1161/cir.0000000000001106

[8] Philouze, P., Cortet, M., Quattrone, D., Céruse, P., Aubrun, F., Dubernard, G., Mabrut, J., Delignette, M., & Mohkam, K. (2020). Surgical activity during the Covid-19 pandemic: Results for 112 patients in a French tertiary care center, a quality improvement study. International Journal of Surgery, 80, 194–201. https://doi.org/10.1016/j.ijsu.2020.07.023

[9] Regmi, M., Wang, Y., Liu, W., Dai, Y., Liu, S., Ma, K., Lin, G., Yang, J., Liu, H., Wu, J., & Yang, C. (2024). From glioma gloom to immune bloom: unveiling novel immunotherapeutic paradigms-a review. Journal of Experimental & Clinical Cancer Research, 43(1). https://doi.org/10.1186/s13046-024-02973-5

[10] Rodriguez, G., Whiting, E., & Lee, J. (2024). ERAS Protocols and Multimodal Pain Management in Surgery. In IntechOpen eBooks. https://doi.org/10.5772/intechopen.111899

[11] Steffel, J., Collins, R., Antz, M., Cornu, P., Desteghe, L., Haeusler, K. G., Oldgren, J., Reinecke, H., Roldan-Schilling, V., Rowell, N., Sinnaeve, P., Vanassche, T., Potpara, T., Camm, A. J., Heidbüchel, H., Lip, G. Y. H., Deneke, T., Dagres, N., Boriani, G., . . . Field, M. (2021). 2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation. EP Europace, 23(10), 1612–1676. https://doi.org/10.1093/europace/euab065

[12] Sundaresan, S., Gu, Y., Gu, H., Salomón, M., -Sánchez, A., Pianoschi, T., Bey, E., Motea, E., Singh, N., Huang, X., Pay, S., Starcher, C., Silver, J., Yeh, I., Su, X., Russ, K., Fitzgerald, T., Lastraioli, E., Iorio, J., . . . Xii, T. (2021). Translational Research in Cancer. In IntechOpen eBooks. https://doi.org/10.5772/intechopen.73772

[13] Zhao, X., Chen, L., Huang, F., Huang, Z., & Zhou, H. (2023). Enhanced Recovery after Surgery in patients undergoing total joint arthroplasty: A retrospective study. Pakistan Journal of Medical Sciences, 39(3). https://doi.org/10.12669/pjms.39.3.7169

Downloads

Published

14-10-2024

Issue

Section

Articles

How to Cite

Wang, J., & Agunod, C. D. (2024). Evaluating the Impact of Enhanced Recovery After Surgery (ERAS) on Postoperative Outcomes in Pancreatic Cancer Patients: A Historical Control Study. International Journal of Public Health and Medical Research, 2(2), 21-32. https://doi.org/10.62051/ijphmr.v2n2.04