The Fisetin on Anti-senescence of Hepatocellular Carcinoma Cell

Abstract

Liver cancer, as a global health issue, is of critical importance in termsal of treatment and prognosis. Quercetin, a flavonoid compound widely found in fruits, vegetables, and beverages, has become a research focus in recent years for its antioxidant, anti-inflammatory, anti-viral, and anti-tumor properties. Studies, especially on the inhibition of hepatocellular growth, the blocking of metastasis, and the regulation of cellular senescence mechanisms, have suggested that quercetin has potential therapeutic value. This article primarily reviews the progress of quercetin in the anti-senescence research of liver cancer cells. Studies have shown that quercetin can affect the proliferation, survival, and apoptosis of liver cancer cells through different molecular mechanisms. Firstly, quercetin can directly inhibit the growth of liver cancer cells by inducing cell cycle arrest at the G0/G1 or G2/M phases, and by upregulating pro-apoptotic proteins such as the caspase family and downregulating anti-apoptotic proteins like the Bcl-2 family, thereby promoting apoptosis of liver cancer cells. Secondly, quercetin can inhibit the invasion and metastasis of liver cancer cells, which may be related to its regulation of matrix metalloproteinase expression, significant in preventing distant metastases of liver cancer. Furthermore, quercetin can influence the biological behaviors of liver cancer cells by regulating related signaling pathways, such as PI3K/Akt, MAPKs, and NF-κB. In addition, quercetin exhibits a unique mechanism in regulating the senescence of liver cancer cells by promoting senescence through the activation of the p53/p21 and p16/Rb pathways. Finally, addressing the issue of quercetin's bioavailability, research has found that combining it with other drugs or improving the administration methods could enhance its therapeutic effect. In summary, as a multi-target natural compound, quercetin shows extensive potential in the treatment of liver cancer. However, its application in clinical therapy still requires further in vitro, in vivo experiments, and clinical studies to validate its effectiveness and safety.