Retinoic Acid and Its Derivatives in Dermatological Disorders

Wei Jiang; Xueyong Wang; Xiaodong Duan; Shan Li; Nan Li; Jiatai Dou

doi:10.62051/ijphmr.v1n3.01

Authors

Wei Jiang
Xueyong Wang
Xiaodong Duan
Shan Li
Nan Li
Jiatai Dou

DOI:

https://doi.org/10.62051/ijphmr.v1n3.01

Keywords:

Retinoids, Retinoic acid receptor, All-trans-retinoic acid, Dermatology

Abstract

Retinoids are a group of compounds consisting of vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids can regulate the physiological functions of various organs and tissues and play an important role in normalising immune function, cell growth and differentiation. Vitamin A Vitamin A derivatives have a role in the treatment of tumours and ATRA has a role in the differentiation therapy of acute promyelocytic leukaemia (APL). ATRA and other retinoids also have many applications in dermatological conditions (e.g. skin cancer, psoriasis). ATRA and other retinoids also have many applications in dermatological conditions (e.g. skin cancer, psoriasis, acne and ichthyosis). In addition, the physiological functions of skin cells can also be regulated by modulating retinoic acid receptors and retinoid X (or rexinoid) receptors. The results of numerous genetic modelling experiments have shown that the regulation of retinoic acid receptors (RARs) and retinoid X (or rexinoid) receptors (RXRs) may have great potential for the treatment of serious skin diseases such as skin cancer. Here, we provide a synopsis of the main advances in understanding the role of ATRA and its receptors in dermatology.

References

Kostetskii I, Yuan SY, Kostetskaia E, et al. Initial retinoid requirement for early avian development coincides with retinoid receptor coexpression in the precardiac fields and induction of normal cardiovascular development. Dev Dyn. 1998;213(2):188-198.

Xavier-Neto J, Sousa Costa AM, Figueira AC, et al. Signaling through retinoic acid receptors in cardiac development: Doing the right things at the right times. Biochim Biophys Acta. 2015;1849(2):94-111.

Iulianella A, Beckett B, Petkovich M, Lohnes D. A molecular basis for retinoic acid-induced axial truncation. Dev Biol. 1999;205(1):33-48.

Escriva H, Holland ND, Gronemeyer H, Laudet V, Holland LZ. The retinoic acid signaling pathway regulates anterior/posterior patterning in the nerve cord and pharynx of amphioxus, a chordate lacking neural crest. Development. 2002;129(12):2905-2916.

Berenguer M, Duester G. Retinoic acid, RARs and early development. J Mol Endocrinol. 2022;69(4): T59-T67.

Duester G. Towards a Better Vision of Retinoic Acid Signaling during Eye Development. Cells. 2022;11(3).

Abbou T, Bendelac-Kapon L, Sebag A, Fainsod A. Enhanced Loss of Retinoic Acid Network Genes in Xenopus laevis Achieves a Tighter Signal Regulation. Cells. 2022;11(3).

Ghyselinck NB, Duester G. Retinoic acid signaling pathways. Development. 2019;146(13).

Metzler MA, Raja S, Elliott KH, et al. RDH10-mediated retinol metabolism and RARalpha-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development. 2018;145(15).

Samarut E, Fraher D, Laudet V, Gibert Y. ZebRA: An overview of retinoic acid signaling during zebrafish development. Biochim Biophys Acta. 2015;1849(2):73-83.

di Masi A, Leboffe L, De Marinis E, et al. Retinoic acid receptors: from molecular mechanisms to cancer therapy. Mol Aspects Med. 2015; 41:1-115.

Gutierrez-Mazariegos J, Schubert M, Laudet V. Evolution of retinoic acid receptors and retinoic acid signaling. Subcell Biochem. 2014; 70:55-73.

Paschaki M, Schneider C, Rhinn M, et al. Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling. PLoS One. 2013;8(4): e62274.

Samarut E, Rochette-Egly C. Nuclear retinoic acid receptors: conductors of the retinoic acid symphony during development. Mol Cell Endocrinol. 2012;348(2):348-360.

Cai AQ, Radtke K, Linville A, Lander AD, Nie Q, Schilling TF. Cellular retinoic acid-binding proteins are essential for hindbrain patterning and signal robustness in zebrafish. Development. 2012;139(12):2150-2155.

Romeih M, Cui J, Michaille JJ, Jiang W, Zile MH. Function of RARgamma and RARalpha2 at the initiation of retinoid signaling is essential for avian embryo survival and for distinct events in cardiac morphogenesis. Dev Dyn. 2003;228(4):697-708.

Linville A, Radtke K, Waxman JS, Yelon D, Schilling TF. Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches. Dev Biol. 2009;325(1):60-70.

Ishibashi T, Nakazawa M, Ono H, Satoh N, Gojobori T, Fujiwara S. Microarray analysis of embryonic retinoic acid target genes in the ascidian Ciona intestinalis. Dev Growth Differ. 2003;45(3):249-259.

Parihar M, Bendelac-Kapon L, Gur M, et al. Retinoic Acid Fluctuation Activates an Uneven, Direction-Dependent Network-Wide Robustness Response in Early Embryogenesis. Front Cell Dev Biol. 2021; 9:747969.

Bernheim S, Meilhac SM. Mesoderm patterning by a dynamic gradient of retinoic acid signalling. Philos Trans R Soc Lond B Biol Sci. 2020;375(1809):20190556.

Cui J, Michaille JJ, Jiang W, Zile MH. Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by retinoic acid. Dev Biol. 2003;260(2):496-511.

Li C, Hu R, Hou N, et al. Alteration of the Retinoid Acid-CBP Signaling Pathway in Neural Crest Induction Contributes to Enteric Nervous System Disorder. Front Pediatr. 2018; 6:382.