Anticancer Mechanism of Novel Metal Drugs with Different Metal Centers

Zhouyu Liao

doi:10.62051/ijphmr.v1n2.08

Authors

Zhouyu Liao

DOI:

https://doi.org/10.62051/ijphmr.v1n2.08

Keywords:

[Pt (4-(2-quin)-terpy) Cl] (SO3CF3), [Auʹ (4-(2-quin)-terpy) Cl] 2 • CH3CN (PF6), [Cu (4ʹ-(2-quin)- terpy) Cl] [PF6), Metal drug, Anticancer mechanism

Abstract

This study aims to explore new metal drugs with different metal center-[Pt (4ʹ-(2-quin)-terpy) Cl] (SO3CF3), [Auʹ (4-(2-quin)-terpy) Cl] 2 • CH3CN (PF6), [Cu (4ʹ-(2-quin)-terpy) Cl] (PF6) in anticancer therapy and its mechanism of action. The three metal complexes were synthesized by chemical synthesis, and their structures were identified by means of NMR, mass spectrometry and single crystal X-ray diffraction. In vitro anticancer activity evaluation showed that these metal drugs showed different degrees of inhibitory effects on selected cancer cell lines, and the anticancer activity of [Pt (4ʹ-(2-quin)-Terpy)Cl] (SO3CF3) was the most significant. Further mechanism studies revealed that these metal drugs exert anti-cancer effects mainly through the interaction with DNA and inducing apoptosis of cancer cells. In addition, this study evaluated the toxicity of these drugs to normal cells, providing important safety information for their subsequent clinical use. The research in this paper not only enriches the understanding of anticancer mechanism of metal drugs, but also provides a valuable reference for the development of new, efficient and low-toxicity metal anticancer drugs.

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