Utilization of New Methods for Antibody Drug Conjugates: Research Progress and Future Prospects

Abstract

Cancer has become an obvious health problem and scientists focus on this to help the problem. Antibody drug conjugates (ADC) has been considered as an efficient way to treat cancer. There are already many ways to produce ADC, but traditional methods need long and complicated biochemical process. Synthesis methods with high efficiency need to be found. This article aimed to describe three new methods for ADC synthesis, and it came out that all these three methods have high quality and can be used as a common technology to produce ADC. Also, the safety of ADC and several examples of clinical use for ADC were introduced. It provides a reference for ADC synthesis in a relatively simple chemical process for future research. However, there are still some chemical problems that have not been solved, such as azide derivatives are not easy to obtain and they are not stable enough. Future research can focus on the properties of azide derivatives direction.