Properties, Detection Mechanism and Applications of AuNPs-Based Sensors in Virus Detection

Xinye Liu

doi:10.62051/6hh3vn30

Authors

Xinye Liu

DOI:

https://doi.org/10.62051/6hh3vn30

Keywords:

AuNPs; Sensor; Virus Detection; Detection Mechanism.

Abstract

After the outbreak of COVID-19 pandemic, infections caused by viruses have been proved to be one of the greatest global burdens that causes significant morbidity and mortality over the world. Detecting the virus as early as possible can help achieve early diagnosis of the disease. This will help doctors grasp the precious time of treating patients. Therefore, the rapid and accurate detection of viral pathogens is crucial for the effective control in the spreading of diseases, especially during such global pandemics. In the recent years, varies types of gold nanoparticles (AuNPs) based sensors have emerged since AuNPs have shown great potential in the field of viral diagnostics. This review aims to provide an overview of AuNP-based virus detection strategies. It mainly covers the properties of AuNPs, the detection mechanism, and the applications of these methods, such as colorimetric detection, surface plasmon resonance biosensors, fluorescent detection, and electrochemical detection. This work will contribute to promoting the application of AuNPs in virus diagnosis and detection.

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References

[1] Nii-Trebi NI, Emerging and neglected infectious diseases: insights, advances, and challenges, BioMed Research International 2017 (2017) 1-15 .

[2] Draz MS, Shafiee H, Applications of gold nanoparticles in virus detection, Theranostics 8 (2018) 1985-2017.

[3] Medhi R, Srinoi P, Ngo N, Tran HV, Lee TR, Nanoparticle-based strategies to combat COVID-19. ACS Applied Nano Materials 3 (2020) 8557-8580.

[4] Sardar R, Funston AM, Mulvaney P, Murray RW, Gold nanoparticles: past, present, and future. Langmuir 25 (2009) 13840-13851.

[5] Shawky SM, Bald D, Azzazy HME, Direct detection of unamplified hepatitis C virus RNA using unmodified gold nanoparticles, Clin Biochem 43 (2010) 1163-1168.

[6] Wang X, Li Y, Wang H, Fu Q, Peng J, Wang Y, Du J, Zhou Y, Zhan L, Gold nanorod-based localized surface plasmon resonance biosensor for sensitive detection of hepatitis B virus in buffer, blood serum and plasma, Biosensors and Bioelectronics 26 (2010) 404-410.

[7] Chang YF, Wang SF, Huang JC, Su LC, Yao L, Li YC, Wu SC, Chen YMA, Hsieh JP, Chou C, Detection of swine-origin influenza A (H1N1) viruses using a localized surface plasmon coupled fluorescence fiber-optic biosensor, Biosensors and Bioelectronics 26 (2010) 1068-1073.

[8] Martínez‐Paredes G, González‐García MB, Costa‐García A, Genosensor for SARS virus detection based on Gold nanostructured screen‐printed carbon electrodes, Electroanalysis 21 (2009) 379-385.

[9] Sasidharan A, Monteiro‐Riviere NA, Biomedical applications of gold nanomaterials: opportunities and challenges, Nanomedicine and Nanobiotechnology 7 (2015) 779-796.