Studies on the regulation of cellular activity and gene expression under acetaminophen intervention

Authors

  • Yue Wang

DOI:

https://doi.org/10.62051/ngx4y011

Keywords:

acetaminophen; cellular activity; gene expression regulation; drug intervention; molecular biology; signaling pathways; epigenetics; experimental validation.

Abstract

This study investigated the effects of acetaminophen on the regulation of cellular activities and gene expression. Through a series of in vitro experiments, the effects of acetaminophen on cell proliferation, apoptosis and metabolism at different doses were analyzed and combined with gene expression profiling to reveal its regulatory mechanisms at the level of signaling pathways, transcription factor regulation and epigenetics. The results indicate that acetaminophen can significantly alter cell physiology and gene expression, suggesting its potential role and risk in drug intervention. This study provides new insights into the clinical application of acetaminophen and provides a theoretical basis for individualized therapy and drug optimization.

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References

[1] Rahme E , Choquette D , Beaulieu M ,et al.Impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population[J].American Journal of Medicine, 2005, 118(11):1262-1270.DOI:10.1016/j.amjmed.2005.03.026.

[2] Schindler B A , Shook J , Schwartz G M .Beneficial effects of psychiatric intervention on recovery after coronary artery bypass graft surgery[J].General Hospital Psychiatry, 1989, 11(5):358-364.DOI:10.1016/0163-8343(89)90124-2.

[3] Bernardi A , Jacques-Silva M C ,Andrés Delgado-Ca?edo,et al.Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines[J].European Journal of Pharmacology, 2006, 532(3):214-222.DOI:10.1016/j.ejphar.2006.01.008.

[4] Cordain L .Ultraviolet radiation represents an evolutionary selective pressure for the south-to-north gradient of the MTHFR 677TT genotype[J].American Journal of Clinical Nutrition, 2006, 61(1):100-102.DOI:10.1163/156854091X00579.

[5] Maclaren R , Kuhl D A , Gervasio J M ,et al.Journal of Parenteral and Enteral Nutrition[J].Jpen Journal of Parenteral & Enteral Nutrition, 2011, 35(1):438-444.DOI:10.1177/0148607110396073.

[6] Zhang, Yandong B , Yaning C ,et al.Protective effect of Chushizi(Fructus Broussonetiae) on acetaminophen-induced rat hepatitis by inhibiting the Toll-like receptor 3/c-Jun N-terminal kinase/c-jun/c-fos/janus protein tyrosine kinase/activators of transcription 3 pathway[J].Journal of Traditional Chinese Medicine, 2020, v.40(06):78-86.DOI:10.19852/j.cnki.jtcm.2020.06.008.

[7] Van E M J , Blom Wendy A M , Ben V O ,et al.High-protein and high-carbohydrate breakfasts differentially change the transcriptome of human blood cells[J].American Journal of Clinical Nutrition, 2006, 84(5):1233-1241.DOI:10.1186/1743-7075-3-39.

[8] Decosterd I , Hugli O ,Emmanuel Tamchès,et al.Oligoanalgesia in the Emergency Department: Short-Term Beneficial Effects of an Education Program on Acute Pain[J].Annals of Emergency Medicine, 2007, 50(4):462-471.DOI:10.1016/j.annemergmed.2007.01.019.

[9] Tsai C L , Chang W T , Weng T I ,et al.A patient-tailored N-acetylcysteine protocol for acute acetaminophen intoxication[J].Clinical Therapeutics, 2005, 27(3):336-341.DOI:10.1016/j.clinthera.2005.03.002.

[10] Sa’ed H. Zyoud, Awang R , Sulaiman S A S ,et al.Assessing the Impact of Vomiting Episodes on Outcome after Acetaminophen Poisoning[J].Basic & Clinical Pharmacology & Toxicology, 2010, 107(5):887-892.DOI:10.1111/j.1742-7843.2010.00594.x.

[11] Boinpally R , Spaventa J , Chen K ,et al.Evaluation of the Pharmacokinetic Interaction and Safety of Atogepant Co-Administered with Acetaminophen or Naproxen in Healthy Participants: A Randomized Trial[J].Clinical Drug Investigation, 2021, 41(6):557-567.DOI:10.1007/s40261-021-01034-5.

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Published

24-12-2024

How to Cite

Wang, Y. (2024). Studies on the regulation of cellular activity and gene expression under acetaminophen intervention. Transactions on Materials, Biotechnology and Life Sciences, 7, 68-73. https://doi.org/10.62051/ngx4y011