The Purpose of Researching Amyotrophic Lateral Sclerosis

Authors

  • Rui Hou

DOI:

https://doi.org/10.62051/35fkx115

Keywords:

Amyotrophic lateral sclerosis, Biomarkers of target engagement, Treatment.

Abstract

The neurological system is affected by a disease called amyotrophic lateral sclerosis that affects nerve cells in the brain and spinal cord. This paper examines several facets of the disease's presentation characteristics, alterations in the illness, and contributing variables and therapeutic approaches. Speech slurring, difficulty swallowing, and arm or leg twitching and paralysis are common initial symptoms of amyotrophic lateral sclerosis. ALS gradually weakens the capacity to control the muscles involved in breathing, eating, speaking, and moving. The brain's capacity to start and regulate voluntary motions is lost. The muscles eventually become non-functional, twitch (a condition known as fasciculations), and atrophy (the loss of muscle mass). This sickness will be caused by a multitude of elements, such as age, gender, and certain genetic information. Additionally, topics like the signs and symptoms of ALS and the possible "treatments" for the illness are covered. There is essentially no chance of a cure for this deadly illness. The symptoms worsen with time because the condition is progressive. That does not, however, imply that individuals should give up looking for a remedy.

Downloads

Download data is not yet available.

References

[1] Rowland, Lewis P., and Neil A. Shneider. "Amyotrophic lateral sclerosis." New England Journal of Medicine 344.22 (2001): 1688-1700.

[2] Hardiman, O., Al-Chalabi, A., Chio, A. et al. Amyotrophic lateral sclerosis. Nat Rev Dis Primers 3, 17071 (2017). https://doi.org/10.1038/nrdp.2017.71

[3] Amyotrophic lateral sclerosis,van Es, Michael A et al. The Lancet, Volume 390, Issue 10107, 2084 - 2098

[4] Amyotrophic lateral sclerosis, Kiernan, Matthew C et al. The Lancet, Volume 377, Issue 9769, 942 - 955

[5] Siddique, Teepu, and Han-**ang Deng. "Genetics of amyotrophic lateral sclerosis." Human molecular genetics 5. Supplement_1 (1996): 1465-1470.

[6] Björn Oskarsson, Tania F. Gendron, Nathan P. Staff, Amyotrophic Lateral Sclerosis: An Update for 2018, Mayo Clinic Proceedings,Volume 93, Issue 11, 2018, Pages 1617-1628

[7] Morgan, Sarah, and Richard W. Orrell. "Pathogenesis of amyotrophic lateral sclerosis." British medical bulletin 119.1 (2016): 87-97.

[8] Jackson, Carlayne E., and Wilson W. Bryan. "Amyotrophic lateral sclerosis." Seminars in neurology. Vol. 18. No. 01. © 1998 by Thieme Medical Publishers, Inc., 1998.

[9] BJ Beck,Felicia A. Smith,Theodore A. Stern,Mental Disorders Due to Another Medical Condition, Massachusetts General Hospital Comprehensive Clinical Psychiatry, (218-239), (2025).

[10] Zarei, Sara, et al. "A comprehensive review of amyotrophic lateral sclerosis." Surgical neurology international 6 (2015).

Downloads

Published

26-11-2024

How to Cite

Hou, R. (2024) “The Purpose of Researching Amyotrophic Lateral Sclerosis”, Transactions on Environment, Energy and Earth Sciences, 3, pp. 440–443. doi:10.62051/35fkx115.