Different Modalities and Parameters in Spinal Cord Stimulation Treatment
DOI:
https://doi.org/10.62051/9rxn6218Keywords:
Spinal cord stimulation; Neurostimulation; Bioelectronics.Abstract
Electrical stimulation to treat diseases can be tranced back to the pharaonic era. Since then, people have found using the electrical pulse generated by electric cat-fish can mange the patient’s pain effectively. Foreign studies started early, and the technology was relatively mature. Spinal cord stimulation was produced in the 1960s by inserting stimulating electrodes into the spinal canal's epidural area. At the same time, the pulse generator was implanted subcutaneously to achieve the purpose of pain treatment with electrical pulses. This article will introduce three main types of stimulation mechanism: constant voltage stimulation, constant current stimulation and activation of the charge mode. Compare the impact of the given stimulus with the design's complexity. However, because the electrode impedance varies with position and time, it is difficult to precisely control the charge of the stimulus, resulting in difficulty in controlling the net charge balance. Secondly, introduce the different parameters and their role in spinal cord stimulation, including the threshold of the cell membrane decide if it can generate the action potential. And the relationship between stimulation amplitude and pulse width, the current intensity is gradually reduced with the grow of stimulation pulse width. And the frequency and waveform, these parameters influence each other and are considered as the most important factors for the patients’ pain management in SCS.
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World Health Organization. Spinal cord injury. World Health Organization, Nov. 2013. From http://www.who.int/mediacentre/factsheets/fs384/en/
Luan S, Constandinou T G. A charge-metering method for voltage-mode neural stimulation[J]. Journal of neuroscience methods, 2014, 224: 39-47. DOI: https://doi.org/10.1016/j.jneumeth.2013.11.028
Fischler M A, Bolles R C. Random sample consensus: a paradigm for model fitting with applications to image analysis and automated cartography[J]. Communications of the ACM, 1981, 24(6): 381-395. DOI: https://doi.org/10.1145/358669.358692
Zhang J. Basic neural units of the brain: neurons, synapses and action potential[J]. arXiv preprint arXiv:1906.01703, 2019.
Melzack R, Wall P D. Pain Mechanisms: A New Theory: A gate control system modulates sensory input from the skin before it evokes pain perception and response[J]. Science, 1965, 150(3699): 971-979. DOI: https://doi.org/10.1126/science.150.3699.971
Vallejo R, Bradley K, Kapural L. Spinal cord stimulation in chronic pain[J]. Spine, 2017, 42(1): S53-S60. DOI: https://doi.org/10.1097/BRS.0000000000002179
Blair E A, Erlanger J. A comparison of the characteristics of axons through their individual electrical responses[J]. American Journal of Physiology-Legacy Content, 1933, 106(3): 524-564. DOI: https://doi.org/10.1152/ajplegacy.1933.106.3.524
Lee H M, Ghovanloo M. Power-efficient wireless neural stimulating system design for implantable medical devices[J]. IEIE Transactions on Smart Processing & Computing, 2015, 4(3): 133-140. DOI: https://doi.org/10.5573/IEIESPC.2015.4.3.133
North R B, Kidd D H, Zahurak M, et al. Spinal cord stimulation for chronic, intractable pain: experience over two decades[J]. Neurosurgery, 1993, 32(3): 384-395. DOI: https://doi.org/10.1097/00006123-199303000-00008
Barolat G. Current status of epidural spinal cord stimulation[J]. Neurosurgery Quarterly, 1995, 5(2): 98-124. DOI: https://doi.org/10.1097/00013414-199506000-00002
Holsheimer J. Effectiveness of spinal cord stimulation in the management of chronic pain: analysis of technical drawbacks and solutions[J]. Neurosurgery, 1997, 40(5): 990-999. DOI: https://doi.org/10.1097/00006123-199705000-00023
Han J S. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies[J]. Trends in neurosciences, 2003, 26(1): 17-22. DOI: https://doi.org/10.1016/S0166-2236(02)00006-1
Van Buyten J P, Al-Kaisy A, Smet I, et al. High-frequency spinal cord stimulation for the treatment of chronic back pain patients: results of a prospective multicenter European clinical study[J]. Neuromodulation: Technology at the Neural Interface, 2013, 16(1): 59-66. DOI: https://doi.org/10.1111/ner.12006
Sato K L, King E W, Johanek L M, et al. Spinal cord stimulation reduces hypersensitivity through activation of opioid receptors in a frequency-dependent manner[J]. European journal of pain, 2013, 17(4): 551-561. DOI: https://doi.org/10.1002/j.1532-2149.2012.00220.x
Gao J, Wu M, Li L, et al. Effects of spinal cord stimulation with “standard clinical” and higher frequencies on peripheral blood flow in rats[J]. Brain research, 2010, 1313: 53-61. DOI: https://doi.org/10.1016/j.brainres.2009.11.072
Shechter R, Yang F, Xu Q, et al. Conventional and kilohertz-frequency spinal cord stimulation produces intensity-and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain[J]. Anesthesiology, 2013, 119(2): 422-432. DOI: https://doi.org/10.1097/ALN.0b013e31829bd9e2
Merrill D R, Bikson M, Jefferys J G R. Electrical stimulation of excitable tissue: design of efficacious and safe protocols[J]. Journal of neuroscience methods, 2005, 141(2): 171-198. DOI: https://doi.org/10.1016/j.jneumeth.2004.10.020
Ativanichayaphong T, He J W, Hagains C E, et al. A combined wireless neural stimulating and recording system for study of pain processing[J]. Journal of neuroscience methods, 2008, 170(1): 25-34. DOI: https://doi.org/10.1016/j.jneumeth.2007.12.014
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