Optimization and Efficacy Evaluation of NADES-Based Green Extraction for Total Flavonols from Eleutherine plicata Herb

Xi Li; Ping He; Jie Guo; Xurundong Kan; Chunying Peng; Xueling Li

doi:10.62051/ijafsr.v4n2.01

Authors

Xi Li
Ping He
Jie Guo
Xurundong Kan
Chunying Peng
Xueling Li

DOI:

https://doi.org/10.62051/ijafsr.v4n2.01

Keywords:

Natural deep eutectic solvent (NADES), Eleutherine plicata Herb, Total flavonols, Extraction optimization

Abstract

Flavonols in Eleutherine plicata have significant pharmacological value, but traditional extraction is inefficient and toxic. A green NADES system (3 sugars as HBDs, 2 acids as HBAs) was screened, characterized, and optimized by single-factor/orthogonal tests. Xylose-citric acid NADES performed best (16.81%, typical NADES properties). Optimized conditions: xylose/citric acid 1:4, 15% water, 1:2 solid-liquid ratio, 50℃/50 min. Validation yielded 24.42% (RSD=1.96%), far exceeding traditional methods (≈1.97%), and stable. This system solves the low-efficiency issue and provides a reference for natural flavonoid extraction.

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